Name | Desflurane |
Synonyms | DESFLURANE Desflurane 1,2,2,2-TETRAFLUOROETHYL DIFLUOROMETHYL ETHER DIFLUOROMETHYL 1,2,2,2-TETRAFLUOROETHYL ETHER (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane |
CAS | 57041-67-5 |
Molecular Formula | C3H2F6O |
Molar Mass | 168.04 |
Density | 1,47 g/cm3 |
Boling Point | 23-24°C |
Refractive Index | 1.3577 (estimate) |
Physical and Chemical Properties | Chemical properties Volatile liquid, boiling point 23.5 ℃. D 1.44. |
Use | Use of inhaled anesthetics, which induce and recover quickly, and anesthetic efficacy is lower than other halogenated agents. For anesthesia. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 23 - Toxic by inhalation |
HS Code | 2909191800 |
Hazard Class | GAS |
Raw Materials | Isoflurane Desflurane Ethane, 2-(dichloromethoxy)-1,1,1,2-tetrafluoro- BROMINE TRIFLUORIDE |
Downstream Products | Ethane, pentafluoro(trifluoromethoxy)- 2-Chloro-1,1,1,2-tetrafluoroethane |
solubility | Practically insoluble in water, miscible with anhydrous ethanol. |
EPA chemical information | Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-, ( -)- (57041-67-5) |
Hazard Note | Irritant |
toxic substance data | 57041-67-5(Hazardous Substances Data) |
overview
Desflurane is similar to isoflurane (CHF2-O-CHCl-CF3), both are halogen compounds of methyl ethane, but fluorine is used in the α-ethyl part instead of chlorine. The halogenation of fluorine can reduce the solubility of blood and tissues, change the boiling point, vapor pressure and stability of desflurane, and enhance its molecular stability and anti-biodegradation and anti-alkaline degradation.
production method
Isoflurane and bromine trifluoride react overnight at room temperature to obtain desflurane with 62% yield.