57103-51-2
Nauclefine
CAS: 57103-51-2
Molecular Formula: C18H13N3O
57103-51-2 - Names and Identifiers
| Name | Nauclefine |
| Synonyms | Nauclefine |
| CAS | 57103-51-2 |
57103-51-2 - Physico-chemical Properties
| Molecular Formula | C18H13N3O |
| Molar Mass | 287.32 |
| Melting Point | 285-290°C |
| Appearance | Yellow powder |
| Storage Condition | 2-8℃ |
57103-51-2 - Introduction
Nauclefine is an organic compound with the chemical formula C27H29NO2S. It is a yellow solid, practically insoluble in water, but soluble in organic solvents such as ethanol and dichloromethane.
Nauclefine is a catalytic reagent, which is commonly used in reduction and rearrangement reactions in organic synthesis reactions. It can be used as a chiral acidic catalyst for asymmetric reduction, e.g. for asymmetric reduction of Aromatic ketones. In addition, it can also participate in some metal-catalyzed reactions, such as the Suzuki reaction of aryl borate esters and the isomerization reaction of phosphate esters.
The preparation method of Nauclefine is complicated. One common method of preparation is synthesis by a three-step reaction. First, a benzylidene bromide is reacted with a primary amine to form the corresponding amine. The amine is then reacted with diethyl sulfate, catalyzed by hydrogen iodide, to form the thiol. Finally, the thiol is reacted with isopropyl methacrylate to give the Nauclefine.
Regarding the safety information of Nauclefine, since it is an organic compound, it may be irritating and toxic. Therefore, it is necessary to take appropriate protective measures during operation, such as wearing gloves, protective glasses and respiratory protection equipment. At the same time, it should be operated in a well-ventilated laboratory and avoid contact with the skin or inhalation of its gases. If splashed into the eyes or skin, rinse immediately with plenty of water and seek medical help. It is best to use Nauclefine under professional guidance and follow the correct aerosol handling practices.
Nauclefine is a catalytic reagent, which is commonly used in reduction and rearrangement reactions in organic synthesis reactions. It can be used as a chiral acidic catalyst for asymmetric reduction, e.g. for asymmetric reduction of Aromatic ketones. In addition, it can also participate in some metal-catalyzed reactions, such as the Suzuki reaction of aryl borate esters and the isomerization reaction of phosphate esters.
The preparation method of Nauclefine is complicated. One common method of preparation is synthesis by a three-step reaction. First, a benzylidene bromide is reacted with a primary amine to form the corresponding amine. The amine is then reacted with diethyl sulfate, catalyzed by hydrogen iodide, to form the thiol. Finally, the thiol is reacted with isopropyl methacrylate to give the Nauclefine.
Regarding the safety information of Nauclefine, since it is an organic compound, it may be irritating and toxic. Therefore, it is necessary to take appropriate protective measures during operation, such as wearing gloves, protective glasses and respiratory protection equipment. At the same time, it should be operated in a well-ventilated laboratory and avoid contact with the skin or inhalation of its gases. If splashed into the eyes or skin, rinse immediately with plenty of water and seek medical help. It is best to use Nauclefine under professional guidance and follow the correct aerosol handling practices.
Last Update：2024-04-10 22:29:15
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Product Name: Nauclefine Visit Supplier Webpage Request for quotation
CAS: 57103-51-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 57103-51-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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