57805-85-3

57805-85-3 - Names and Identifiers

Name	methyl 3-aminobenzofuran-2-carboxylate
Synonyms	4-Chlorobenzofuro[3,2-d]pyrimidine methyl3-amino-2-benzofurancarboxylate methyl 3-amino-2-benzofurancarboxylate methyl 3-aminobenzofuran-2-carboxylate METHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE Methyl3-aminobenzo[b]furan-2-carboxylate Methyl 3-amino-1-benzofuran-2-carboxylate METHYL 3-AMINO-1-BENZOFURAN-2-CARBOXYLATE 3-Amino-benzofuran-2-carboxylic acid methyl ester 3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER 2-Benzofurancarboxylic acid, 3-amino-, methyl ester
CAS	57805-85-3
InChI	InChI=1/C10H9NO3/c1-13-10(12)9-8(11)6-4-2-3-5-7(6)14-9/h2-5H,11H2,1H3

57805-85-3 - Physico-chemical Properties

Molecular Formula	C10H9NO3
Molar Mass	191.18
Density	1.304±0.06 g/cm3(Predicted)
Melting Point	82-84 °C(Solv: benzene (71-43-2))
Boling Point	317.5±22.0 °C(Predicted)
Flash Point	145.823°C
Vapor Presure	0mmHg at 25°C
pKa	0.41±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.634

57805-85-3 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

57805-85-3 - Introduction

Methyl is an organic compound with the chemical formula C10H9NO3. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless to light yellow crystalline or powdery solid.
-Melting point: about 100-102 ℃.
-Solubility: Soluble in alcohol and ether, slightly soluble in water.
-chemical reaction: can occur through esterification and acid ester exchange, hydrolysis reaction.

Use:
-Drug synthesis: As an intermediate compound, methyl is often used to prepare drugs or drug candidate compounds containing benzofuran structures.
-Analytical chemistry: In the fields of fluorescence analysis, chromatography, etc., methyl can be used as a fluorescent probe or marker.

Preparation Method:
Common synthetic methods for methyl include:
1. amination reaction: the reaction of para-benzenediol and dimethylformamide, and then through esterification reaction to obtain the target product.
2. amination-esterification reaction: condensation of para-benzenediol with trimethylamine, and then acid-catalyzed esterification reaction to obtain the target product.

Safety Information:
- methyl toxicity is low, but still need to pay attention to protective measures.
-Wear appropriate protective equipment, such as chemical protective gloves, protective goggles and protective face masks.
-Avoid contact with skin, eyes and mucous membranes. If there is contact, rinse immediately with plenty of water.
-Operate in a well-ventilated place to avoid inhaling its vapor or dust.
-Keep away from fire and heat sources to avoid fire or explosion.
-Store in a sealed manner, away from acids, oxidants and combustibles.

Please note that when handling this compound, be sure to refer to and follow the relevant safety data sheets and operating instructions for the chemical.

Last Update：2024-04-09 15:17:58