57817-10-4
6-Fluoro-7-methylindole
CAS: 57817-10-4
Molecular Formula: C9H8FN
57817-10-4 - Names and Identifiers
| Name | 6-Fluoro-7-methylindole |
| Synonyms | 6-Fluoro-7-methylindole 6-Fluoro-7-methyl-1H-indole 1H-Indole, 6-fluoro-7-Methyl- 1H-indole, 6-fluoro-7-methyl- 1H-Indole,6-fluoro-7-methyl-(9CI) |
| CAS | 57817-10-4 |
| InChI | InChI=1/C9H8FN/c1-6-8(10)3-2-7-4-5-11-9(6)7/h2-5,11H,1H3 |
57817-10-4 - Physico-chemical Properties
| Molecular Formula | C9H8FN |
| Molar Mass | 149.16 |
| Density | 1.219±0.06 g/cm3(Predicted) |
| Melting Point | 77-82°C |
| Boling Point | 265.0±20.0 °C(Predicted) |
| Flash Point | 114.056°C |
| Vapor Presure | 0.015mmHg at 25°C |
| pKa | 16.70±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.627 |
57817-10-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
57817-10-4 - Introduction
6-Fluoro-7-methylindole is an organic compound with the chemical formula C9H8FN and a molecular weight of 158.17g/mol. The following are the properties, use, preparation and safety information of the compound:
Nature:
-Appearance: 6-Fluoro-7-methylindole is a colorless or light yellow to brown crystal.
-Melting point: about 56-58°C.
-Boiling point: about 260°C.
-Solubility: Soluble in organic solvents such as ethanol, dichloromethane and ether.
Use:
6-Fluoro-7-methylindole is commonly used in organic synthesis and pharmaceutical fields, and is used as a raw material or intermediate for various drugs.
Preparation Method:
The preparation method of 6-Fluoro-7-methylindole can be achieved by the following steps:
1. Suspend the 7-methylindole in anhydrous dichloromethane in an ice bath.
2. Slowly add ammonium bifluoride (NH4F. HF) solution dropwise and keep the reaction temperature below 5°C.
3. After completion of the reaction, the reaction mixture was filtered and then the solvent was evaporated to dryness.
4. 6-Fluoro-7-methyllindole can be obtained by crystallization of the obtained residue.
Safety Information:
- 6-Fluoro-7-methylindole may be irritating to the skin, eyes and respiratory system. Pay attention to safety precautions when using it.
-This compound may be toxic to aquatic organisms and should avoid environmental pollution.
-During storage and handling, keep away from ignition and oxidizing agents, and ensure adequate ventilation for operation.
-Use in accordance with relevant safety procedures and avoid inhalation, swallowing or contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water, and seek medical help if you feel unwell.
Nature:
-Appearance: 6-Fluoro-7-methylindole is a colorless or light yellow to brown crystal.
-Melting point: about 56-58°C.
-Boiling point: about 260°C.
-Solubility: Soluble in organic solvents such as ethanol, dichloromethane and ether.
Use:
6-Fluoro-7-methylindole is commonly used in organic synthesis and pharmaceutical fields, and is used as a raw material or intermediate for various drugs.
Preparation Method:
The preparation method of 6-Fluoro-7-methylindole can be achieved by the following steps:
1. Suspend the 7-methylindole in anhydrous dichloromethane in an ice bath.
2. Slowly add ammonium bifluoride (NH4F. HF) solution dropwise and keep the reaction temperature below 5°C.
3. After completion of the reaction, the reaction mixture was filtered and then the solvent was evaporated to dryness.
4. 6-Fluoro-7-methyllindole can be obtained by crystallization of the obtained residue.
Safety Information:
- 6-Fluoro-7-methylindole may be irritating to the skin, eyes and respiratory system. Pay attention to safety precautions when using it.
-This compound may be toxic to aquatic organisms and should avoid environmental pollution.
-During storage and handling, keep away from ignition and oxidizing agents, and ensure adequate ventilation for operation.
-Use in accordance with relevant safety procedures and avoid inhalation, swallowing or contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water, and seek medical help if you feel unwell.
Last Update：2024-04-09 15:17:58
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