59-48-3
Oxindole
CAS: 59-48-3
Molecular Formula: C8H7NO
59-48-3 - Names and Identifiers
| Name | Oxindole |
| Synonyms | OXINDOL Oxindole OXINDOLE 2-Oxindole NSC 274863 2-indolinone Indolin-2-one Indoline-2-one TIMTEC-BB SBB004215 2,3-dihydroindol-2-one 2-Oxo-2,3-dihydroindole 1,3-dihydro-2h-indol-2-on 1,3-dihydro-2H-indol-2-one O-(Aminophenyl)Acetic acid Lactam O-(AMINOPHENYL)ACETIC ACID LACTAM |
| CAS | 59-48-3 |
| EINECS | 200-429-5 |
| InChI | InChI=1/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10) |
59-48-3 - Physico-chemical Properties
| Molecular Formula | C8H7NO |
| Molar Mass | 133.15 |
| Density | 1.1475 (rough estimate) |
| Melting Point | 123-128°C(lit.) |
| Boling Point | 227°C73mm Hg(lit.) |
| Flash Point | 194-196°C/17mm |
| Water Solubility | insoluble |
| Solubility | 9.1g/l |
| Vapor Presure | 0.000521mmHg at 25°C |
| Appearance | Light brown to yellowish orange powder |
| Color | Light Brown |
| BRN | 114692 |
| pKa | 14.77±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5282 (estimate) |
| MDL | MFCD00005711 |
| Physical and Chemical Properties | White or yellowish crystalline powder, melting point 121-124°C. |
| In vitro study | Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities. |
59-48-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | NM2080500 |
| HS Code | 29337900 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
59-48-3 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | 2-indolinone is a ketone derivative, which can be used as a pharmaceutical intermediate. |
| biological activity | Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound, can cause sedation, muscle weakness, hypotension and Coma. |
| Use | indole analog; Shows pharmacological activity. |
Last Update：2024-04-09 21:21:28
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View History
59-48-3
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4-Ethyl-m-xylene
Monomethylaniline
6324-70-5
(Z)-2-C4H8
氙气
3-(3-CHLOROPHENYL)-2-MERCAPTO-3,5-DIHYDRO-4H-PYRIMIDO[5,4-B]INDOL-4-ONE
41172-51-4
2-Cyclopropylpropan-2-ol
Rocuronium Impurity 12
4-Ethyl-m-xylene
Monomethylaniline
6324-70-5
(Z)-2-C4H8
氙气
3-(3-CHLOROPHENYL)-2-MERCAPTO-3,5-DIHYDRO-4H-PYRIMIDO[5,4-B]INDOL-4-ONE
41172-51-4
2-Cyclopropylpropan-2-ol