59142-68-6
2-Bromo-4-fluorobenzaldehyde
CAS: 59142-68-6
Molecular Formula: C7H4BrFO
59142-68-6 - Names and Identifiers
| Name | 2-Bromo-4-fluorobenzaldehyde |
| Synonyms | 2-BROMO-4-FLUOROBENZALDEHYDE 2-Bromo-4-fluorobenzaldehyde 5-Fluoro-2-formylbromobenzene Benzaldehyde,2-bromo-4-fluoro- Benzaldehyde, 2-bromo-4-fluoro- 4-Bromine-2-Fluoro Benzaldehydes 2 - broMine - 4 - fluoro benzaldehyde |
| CAS | 59142-68-6 |
| InChI | InChI:1S/C7H4BrFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H |
59142-68-6 - Physico-chemical Properties
| Molecular Formula | C7H4BrFO |
| Molar Mass | 203.01 |
| Density | 1.70 |
| Melting Point | 61.5 |
| Boling Point | 234.9±20.0 °C(Predicted) |
| Flash Point | 95.9 °C |
| Appearance | Yellow-like crystals |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD00672923 |
| Physical and Chemical Properties | White powder |
59142-68-6 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R52 - Harmful to aquatic organisms R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29122990 |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, LIGHT SENS |
59142-68-6 - Reference Information
| introduction | 2-bromo -4-fluorobenzaldehyde is an aldehyde organic substance and can be used as a pesticide intermediate. |
| use | 2-bromo -4-fluorobenzaldehyde is an important intermediate used in the synthesis of fluorine-containing drugs and can be used as an important synthetic raw material for prostaglandin D2 inhibitors and other drugs [US 2004/0162323 Al, WO 02/22621 A2]; or a synthetic raw material for benzylamine derivatives [ZL 97194737.6] used to treat depression. Therefore, its synthesis has very important practical value and industrial application prospect. for the synthesis of pharmaceutical and pesticide intermediates |
| synthesis method | for the synthesis of 2-bromo -4-fluorobenzaldehyde, the main synthesis strategies are as follows: 1) oxidation of 2-bromo -4-fluorobenzyl alcohol. Using 2-bromo-4-fluorobenzoic acid as the starting material, through methyl iodide, the product is then reduced to 2-bromo-4-fluorobenzyl alcohol by diisobutylaluminum hydrogen (DIBAL), finally, pyridyl dichromate (PDC) was used to oxidize 2-bromo-4-fluorobenzyl alcohol to 2-bromo-4-fluorobenzaldehyde 2). Another synthetic strategy is to selectively control the reduction of 2-bromo-4-fluorobenzonitrile. |
| chemical properties | white powder |
Last Update：2024-04-09 19:05:03
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