5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
Epoprostenol
CAS: 35121-78-9
Molecular Formula: C20H32O5
5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA - Names and Identifiers
5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA - Physico-chemical Properties
| Molecular Formula | C20H32O5 |
| Molar Mass | 352.47 |
| Density | 1.221 |
| Boling Point | 530.2±50.0 °C(Predicted) |
| pKa | 4.70±0.10(Predicted) |
| Physical and Chemical Properties | It is unstable in aqueous solution and hydrolyzed to form 6-oxo-PGF1α. When the phosphate ester is 0.165mol/L, its half-life is about 14.5min(4 ℃). Sodium Epoprostenol: C20H31NaO5. [61849-14-7]. Hygroscopic and flowable white powder. It can be stored for 2 months at -30 ℃ and when dry. |
5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA - References
| purpose | is a therapeutic drug for primary pulmonary hypertension. |
| production method | compound (I) and 1.1 equivalents of NBS in a mixed solvent of tetrahydrofuran-chloroform, reaction was carried out at 23 ° C. For 1H to obtain compound (II). Compound (II) was hydrolyzed in acetic acid-water-tetrahydrofuran (3:1:1) at 45 °c for 4H to give compound (III). Compound (III) and excess potassium tert-butoxide tert-butanol solution, reaction at 45 ℃ for 1.5h, the reaction solution was concentrated, dissolved in water, adjusted to pH 5, at 0 ℃ with ether rapid extraction, epoprostenol was obtained in a yield of 81% [based on compound (I)]. |
Last Update：2024-04-09 02:00:21
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