5h-(1)benzopyrano(2,3-b)pyridine-3-carboxylicacid,2-amino-7-(1-methylethyl)-5
Amlexanox
CAS: 68302-57-8
Molecular Formula: C16H14N2O4
5h-(1)benzopyrano(2,3-b)pyridine-3-carboxylicacid,2-amino-7-(1-methylethyl)-5 - Names and Identifiers
5h-(1)benzopyrano(2,3-b)pyridine-3-carboxylicacid,2-amino-7-(1-methylethyl)-5 - Physico-chemical Properties
| Molecular Formula | C16H14N2O4 |
| Molar Mass | 298.29 |
| Density | 1.408±0.06 g/cm3(Predicted) |
| Melting Point | >3000C |
| Boling Point | 570.0±50.0 °C(Predicted) |
| Flash Point | 298.5°C |
| Solubility | DMSO: soluble10mg/mL at warmed, clear |
| Vapor Presure | 7.86E-14mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| Merck | 14,490 |
| pKa | 3.95±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Refractive Index | 1.668 |
| Physical and Chemical Properties | White to yellowish white crystals or crystalline powder, odorless and tasteless. Soluble in dimethyl sulfoxide, more soluble in dimethyl formamide, difficult to dissolve in Tetrahydrofuran, very difficult to dissolve in methanol, ethanol or chloroform, a few insoluble in ether, acetonitrile or water. Melting point> 300 °c. Acute toxicity LD50 mice, rats (mg/kg):2320~2370, about 10000 oral. |
| Use | For the treatment of oral ulcers |
5h-(1)benzopyrano(2,3-b)pyridine-3-carboxylicacid,2-amino-7-(1-methylethyl)-5 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S37 - Wear suitable gloves. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DJ3102000 |
| HS Code | 29349990 |
5h-(1)benzopyrano(2,3-b)pyridine-3-carboxylicacid,2-amino-7-(1-methylethyl)-5 - Reference Information
| biological activity | Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory and anti-allergic immunomodulator, it is also an inhibitor of protein kinases TBK1 and IKK-Epsilon. |
| Target | Value |
| Use | has an inhibitory effect on histamine free reaction, an inhibitory effect on leukotriene production, and an antileukotriene effect, thereby producing an antiasthmatic effect. For the treatment of bronchial asthma, allergic rhinitis. for the treatment of oral ulcers |
| production method | in an aqueous solution containing morpholine and dimethylformamide, the reaction was heated at 60 ° C. To obtain compound (II). It is condensed and cyclized with malonic acid monoethyl ester amide, and then hydrolyzed to obtain ammonia. |
Last Update：2024-04-10 22:29:15
Supplier List
Product Name: Amlexanox Request for quotation
CAS: 68302-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 68302-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Amlexanox Visit Supplier Webpage Request for quotationCAS: 68302-57-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Amlexanox Request for quotation
CAS: 68302-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 68302-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Amlexanox Visit Supplier Webpage Request for quotationCAS: 68302-57-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History