6-(1H-PYRAZOL-1-YL)NICOTINONITRILE

6-(1H-PYRAZOL-1-YL)NICOTINONITRILE - Names and Identifiers

Name	6-(1H-Pyrazol-1-yl)nicotinonitrile
Synonyms	6-(1H-Pyrazol-1-yl)nicotinonitrile 6-(1H-PYRAZOL-1-YL)NICOTINONITRILE 6-pyrazol-1-ylpyridine-3-carbonitrile 6-(1H-pyrazol-1-yl)pyridine-3-carbonitrile 6-(1H-Pyrazol-1-yl)-3-pyridinecarbonitrile 3-Pyridinecarbonitrile, 6-(1H-pyrazol-1-yl)- 3-pyridinecarbonitrile, 6-(1H-pyrazol-1-yl)-
CAS	956568-52-8
InChI	InChI=1/C9H6N4/c10-6-8-2-3-9(11-7-8)13-5-1-4-12-13/h1-5,7H

6-(1H-PYRAZOL-1-YL)NICOTINONITRILE - Physico-chemical Properties

Molecular Formula	C9H6N4
Molar Mass	170.17
Density	1.23
Boling Point	336.4±27.0 °C(Predicted)
Flash Point	157.272°C
Vapor Presure	0mmHg at 25°C
pKa	-0.79±0.19(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.663

6-(1H-PYRAZOL-1-YL)NICOTINONITRILE - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S3/9 - S36/37 - Wear suitable protective clothing and gloves.
HS Code	29331990

6-(1H-PYRAZOL-1-YL)NICOTINONITRILE - Introduction

6-(1H-Pyrazol-1-yl)nicotinonitrile is an organic compound with the chemical formula C10H6N4 and a molecular weight of 190.18g/mol. It is a solid, yellow crystalline, soluble in some organic solvents, such as dimethyl sulfoxide and dimethylformamide.

6-(1H-Pyrazol-1-yl)nicotinonitrile has a wide range of applications in the field of medicinal chemistry research. It can be used as an important intermediate for the synthesis of anticancer drugs, anti-inflammatory drugs and other bioactive molecules. It acts as a connecting bridge between 1-pyrazolyl and nicotinic acid in the synthesis of organic compounds, which can give the product specific biological activity.

The method for synthesizing 6-(1H-Pyrazol-1-yl)nicotinonitrile can be prepared by the reaction of phenylalkylamine and pyrazole-1-carboxylic acid chloride. In the reaction, pyrazole -1-carboxamide is first formed, and then it is reacted with nicotinoyl chloride to form the target product.

For safety information, 6-(1H-Pyrazol-1-yl)nicotinonitrile should be handled in accordance with general laboratory procedures. It may be irritating to the skin, eyes and mucous membranes, and direct contact should be avoided. Good ventilation measures should be taken during operation, and protective gloves and goggles should be worn. If contact with skin or eyes occurs, rinse immediately with plenty of water and seek medical help if needed.

In addition, 6-(1H-Pyrazol-1-yl)nicotinonitrile is a chemical and should be stored properly and away from ignition sources and combustibles. When used, stored and handled in accordance with local codes and regulations.

Last Update：2024-04-09 21:54:55