6-(4-chlorophenyl)pyrimidine-2(1H)-thione

6-(4-chlorophenyl)pyrimidine-2(1H)-thione - Names and Identifiers

Name	4-(4-chlorophenyl)pyrimidine-2-thiol
Synonyms	AKOS B020820 BUTTPARK 254-71 ART-CHEM-BB B020820 SALOR-INT L481459-1EA 4-(4-CHLOROPHENYL)PYRIMIDINE-2-THIOL 4-(4-chlorophenyl)pyrimidine-2-thiol 4-(4-Chlorophenyl)-2-mercaptopyrimidine 6-(4-chlorophenyl)pyrimidine-2(1H)-thione 4-(4-Chlorophenyl)-2-MercaptopyriMidine4-(4-chlorophenyl)pyriMid 4-(4-Chlorophenyl)-2-MercaptopyriMidine4-(4-chlorophenyl)pyriMidine-2-thiol
CAS	175203-08-4
InChI	InChI=1/C10H7ClN2S/c11-8-3-1-7(2-4-8)9-5-6-12-10(14)13-9/h1-6H,(H,12,13,14)

6-(4-chlorophenyl)pyrimidine-2(1H)-thione - Physico-chemical Properties

Molecular Formula	C10H7ClN2S
Molar Mass	222.69
Density	1.35g/cm³
Melting Point	210 °C
Boling Point	357.1°C at 760 mmHg
Flash Point	169.8°C
Vapor Presure	2.79E-05mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.674

6-(4-chlorophenyl)pyrimidine-2(1H)-thione - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note	Irritant

6-(4-chlorophenyl)pyrimidine-2(1H)-thione - Introduction

4-(4-chlorophenyl)pyrimidine-2-thiol is an organic compound with the chemical formula C10H7ClN2S. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: 4-(4-chlorophenyl)pyrimidine-2-thiol is a white crystalline solid.
-Solubility: It is soluble in most organic solvents, such as methanol, ethanol and dichloromethane, but difficult to dissolve in water.
-Stability: The compound is relatively stable under regular environmental conditions.

Use:
- 4-(4-chlorophenyl)pyrimidine-2-thiol is widely used in organic synthesis reactions, especially for the synthesis of compounds with important biological activities.
-It can also be used as a raw material for drug intermediates and pesticide intermediates.

Method:
4-(4-chlorophenyl)pyrimidine-2-thiol can be prepared by the following steps:
1. REACTION: first 4-chlorophenol and sulfur sodium chloride reaction to generate the corresponding 4-chlorophenylthiophenol.
2. Bromination: 4-chlorophenyl thiophenol reacts with phosphorus tribromide to generate 4-(4-bromophenyl) pyrimidine -2-thiol.
3. Substitution: The target product is prepared by substituting the bromine atom in 4-(4-bromophenyl) pyrimidine -2-thiol by a chlorine ion-phenol substitution reaction.

Safety Information:
- 4-(4-chroophenyl) pyrimidine-2-thiol has certain toxicity to human body, and attention should be paid to avoid direct contact with skin, inhalation of gas or accidental ingestion.
-When using or handling the compound, be sure to wear appropriate personal protective equipment, such as gloves and goggles.
-When storing and handling this compound, follow safe operating guidelines to ensure that it is kept away from ignition and flammable materials.
-As an organic compound, it should be operated in a well-ventilated place to avoid the accumulation of harmful gases.

Last Update：2024-04-09 02:00:43