6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE

6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE - Names and Identifiers

Name	6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE
Synonyms	6-TRIFLUOROMETHOXYISATIN 6-(trifluoromethoxy)indoline-2,3-dione 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE 1H-Indole-2,3-dione, 6-(trifluoromethoxy)- 6-(trifluoroMethoxy)-2,3-dihydro-1H-indole-2,3-dione
CAS	162252-92-8

6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE - Physico-chemical Properties

Molecular Formula	C9H4F3NO3
Molar Mass	231.13
Density	1.562±0.06 g/cm3(Predicted)
pKa	8.69±0.20(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature

6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE - Introduction

6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE (also known as FMOC) is a commonly used protecting group in organic synthesis. Its chemical formula is C15H10F3NO3, and its relative molecular mass is about 313.24. The following is a description of the properties, uses, formulation and safety information of 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE:

Nature:
-Appearance: 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE is white crystalline powder.
-Melting point: About 142-144 degrees Celsius.
-Solubility: 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE is soluble in most organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane, etc.

Use:
- 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE is commonly used as a protecting group in the synthesis of amino acids and peptides. It can protect the activity on the amino group during the synthesis and prevent premature reaction.
-Because it is easy to remove after the synthesis, 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE is also widely used in the synthesis of peptide and protein fluorescent labels.

Method:
- 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE is generally obtained by reacting isatin with trifluoromethanol. The specific reaction conditions need to be optimized according to the actual situation.

Safety Information:
-When operating 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE, you need to follow safe operating procedures and wear appropriate protective equipment.
- 6-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE has not been identified as a carcinogen, but may pose a potential hazard to the environment and should be handled with caution and proper disposal of waste.
-During use, avoid inhaling dust and contact with skin and eyes. In case of accidental contact, please rinse with plenty of water and seek medical advice.
-It is best to operate in a well-ventilated laboratory environment, away from fire and combustibles.

Last Update：2024-04-10 22:29:15