6-(t-butyldimethylsiloxy)-3,4-dihydro-2h-pyran

6-(t-butyldimethylsiloxy)-3,4-dihydro-2h-pyran - Names and Identifiers

Name	3,4-Dihydro-6-[(Tert-Butyl)Dimethyl Silyloxy]-2H-Pyran
Synonyms	6-(t-butyldimethylsiloxy)-3,4-dihydro-2h-pyran 6-(Tert-Butyldimethylsilyloxy)-3,4-Dihydro-2 H-Pyran 6-(TERT-BUTYLDIMETHYLSILYLOXY)-3,4-DIHYDRO-2 H-PYRAN t-Butyl-Dimethyl-(3,4-Dihydro-2H-Pyran-6-Yloxy)Silane 6-(TERT-BUTYLDIMETHYLSILYLOXY)-3,4- DIHYDRO-2H-PYRANE 6-(Tert-Butyldimethylsilyloxy)-3,4- Dihydro-2H-Pyrane tert-butyl(3,4-dihydro-2H-pyran-6-yloxy)dimethylsilane 3,4-DIHYDRO-6-[(TERT-BUTYL)DIMETHYL SILYLOXY]-2H-PYRAN 3,4-Dihydro-6-[(Tert-Butyl)Dimethyl Silyloxy]-2H-Pyran tert-Butyl((3,4-dihydro-2H-pyran-6-yl)oxy)diMethylsilane 2H-Pyran, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,4-dihydro-
CAS	130650-09-8
InChI	InChI=1/C11H22O2Si/c1-11(2,3)14(4,5)13-10-8-6-7-9-12-10/h8H,6-7,9H2,1-5H3

6-(t-butyldimethylsiloxy)-3,4-dihydro-2h-pyran - Physico-chemical Properties

Molecular Formula	C11H22O2Si
Molar Mass	214.38
Density	0.935 g/mL at 25 °C (lit.)
Boling Point	125-131 °C/28 mmHg (lit.)
Flash Point	177°F
Vapor Presure	0.0827mmHg at 25°C
Specific Gravity	0.935
Storage Condition	2-8°C
Sensitive	7: reacts slowly with moisture/water
Refractive Index	n20/D 1.455(lit.)
Physical and Chemical Properties	WGK Germany:3

6-(t-butyldimethylsiloxy)-3,4-dihydro-2h-pyran - Risk and Safety

WGK Germany

6-(t-butyldimethylsiloxy)-3,4-dihydro-2h-pyran - Introduction

6-(tert-Butyl-dimethylsilyloxy)-3,4-dihydro-2H-pyran, also known as TBDMS-THF, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Solubility: Soluble in common organic solvents, such as ether and acetone
-Melting point:-100°C
-Boiling Point: 67-69°C
-Molecular formula: C10H20O2Si
-Molecular weight: 204.36g/mol

Use:
- TBDMS-THF is widely used in protecting group reactions in organic synthesis, and is often used as a protecting agent for hydroxyl groups.
-It can react with sodium hydroxide to generate an active alkaline reagent, which is then used for acylation, amidation and other reactions.
-It can also be used for the synthesis of pyran derivatives, etherification reactions, amination reactions, etc.

Preparation Method:
The common method for preparing TBDMS-THF is to react pyran with tert-butyl dimethyl chlorosilane under alkaline conditions. After completion of the reaction, the product was obtained by distillation.

Safety Information:
- TBDMS-THF are flammable liquids, should be kept away from open flame and high temperature.
-In use, should take appropriate protective measures, such as wearing chemical protective gloves and goggles.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical treatment if necessary.
-During storage and handling, please follow the safety procedures and store them in a closed, cool and well-ventilated place.

Last Update：2024-04-10 22:29:15