5-Bromo-benzofuran-3-one is an organic compound with the chemical formula C8H4BrO2. The following describes its nature, use, preparation and safety information:
Nature:
5-Bromo-benzofuran-3-one is a white solid with a fragrant odor. It is soluble in organic solvents such as ethanol and dichloromethane at normal temperature. Its melting point is 83-87 degrees Celsius.
Use:
5-Bromo-benzofuran-3-one has some important applications in the field of organic synthesis. It can be used as an intermediate for the synthesis of pharmaceuticals, pesticides and other organic compounds. Its structure containing aromatic ring and carbonyl functional groups makes it highly reactive.
Preparation Method:
The preparation of 5-Bromo-benzofuran-3-one can be achieved by a variety of methods. One commonly used method is by reacting a bromobenzofuranone with an electrophile such as lithium bromide. In the specific step, bromobenzofuranone is first reacted with lithium bromide in an appropriate solvent to obtain a brominated intermediate. The intermediate is then esterified using appropriate basic conditions to give the final product.
Safety Information:
5-Bromo-benzofuran-3-one has no publicly reported risk under normal operating conditions. However, as an organic compound, it may pose a potential threat to human health. Therefore, proper laboratory practices should be followed during use and handling. When conducting experiments, safety measures should be taken, such as wearing suitable protective gloves, glasses and laboratory coats, avoiding contact with skin and eyes, and ensuring that the operation is carried out in a well-ventilated environment.