6-Bromocarbostiryl

6-Bromocarbostiryl - Names and Identifiers

Name	6-bromo-3,4-dihydroquinolin-2(1H)-one
Synonyms	3279-90-1 6-Bromocarbostiryl 6-BroMo-3,4-dihydrocarbostyril 6-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 6-bromo-3,4-dihydroquinolin-2(1H)-one 6-Bromo-3,4-dihydroquinolin-2(1H)-one 6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 6-BROMO-3,4-DIHYDRO-2(1H)-QUINOLINONE 6-BroMo-3,4-dihydro-(1H)-2-quinolinone 2(1H)-Quinolinone, 6-bromo-3,4-dihydro- 6-BROMO-1,2,3,4-TETRAHYDRO-2-QUINOLINONE 6-Bromo-2-oxo-1,2,3,4-tetrahydroquinoline
CAS	3279-90-1
InChI	InChI=1/C9H8BrNO/c10-7-2-3-8-6(5-7)1-4-9(12)11-8/h2-3,5H,1,4H2,(H,11,12)

6-Bromocarbostiryl - Physico-chemical Properties

Molecular Formula	C9H8BrNO
Molar Mass	226.07
Density	1.559±0.06 g/cm3(Predicted)
Melting Point	170-172℃
Boling Point	376.3±42.0 °C(Predicted)
Flash Point	181.352°C
Vapor Presure	0mmHg at 25°C
Appearance	Powder
Color	Brown
pKa	13.92±0.20(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Sensitive	Light Sensitive
Refractive Index	1.6

6-Bromocarbostiryl - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R52 - Harmful to aquatic organisms R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

6-Bromocarbostiryl - Reference Information

application

6-bromo -1,2,3, 4-tetrahydro-2-quinolinone can be used as an intermediate in organic synthesis and a pharmaceutical intermediate, mainly used in laboratory research and development and chemical production.

preparation

3, 4-dihydroquinoline -2(1H)-one (2.73g,18.55mmol) was dissolved in N,N-dimethylacetamide (30mL), and N-bromosuccinimide (3.30g) was slowly added in an ice water bath, 18.55mmol) of N,N-dimethylacetamide (10mL) solution. The reaction solution continued to be stirred in an ice water bath for 6 hours and then heated to room temperature for 12 hours. After the reaction, water (50mL) was added to the reaction mixture and extracted with ethyl acetate (50mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)= 3/1) to obtain a white solid (3.86g,92.1%).

Last Update：2024-04-09 21:54:55