6-Bromoquinazoline-2,4-dione

6-Bromoquinazoline-2,4-dione - Names and Identifiers

Name	6-Bromoquinazoline-2,4-dione
Synonyms	6-bromoquinazoline-2,4-diol 6-Bromoquinazoline-2,4-dione 6-broMo-1,2,3,4-tetrahydroquin 6-bromo-1H-quinazoline-2,4-dione 6-bromoquinazoline-2,4(1H,3H)-dione 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE 6-Bromoquinazoline-2,4(1H,3H)-dione 6-Bromo-1H,3H-quinazoline-2,4-dione 6-Bromo-2,4(1H,3H)-Quinazolinedione 2,4(1H,3H)-Quinazolinedione, 6-bromo- 6-broMo-1,2,3,4-tetrahydroquinazoline-2,4-dione
CAS	88145-89-5
InChI	InChI=1/C8H5BrN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)

6-Bromoquinazoline-2,4-dione - Physico-chemical Properties

Molecular Formula	C8H5BrN2O2
Molar Mass	241.04
Density	1.752±0.06 g/cm3(Predicted)
Melting Point	>300
Appearance	Solid
Color	Off-white
pKa	10.37±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.622
MDL	MFCD00462868

6-Bromoquinazoline-2,4-dione - Risk and Safety

Risk Codes	22 - Harmful if swallowed
UN IDs	UN2811
Hazard Class	IRRITANT

6-Bromoquinazoline-2,4-dione - Reference Information

Use

Chinese alias of 6-bromoquinazolin-2, 4-dione, hexabromoquinazolin-2, 4(1H,3H)-Dione, is a common derivative of quinazolin-2, 4-one. Quinazolinone compounds are a class of important compounds containing pyrimidine heterocyclic compounds, because of its simple structure, easy to modify, is an important intermediate of fine chemical and pharmaceutical synthesis, is widely used in antibacterial, anti-inflammatory, anti-hypertension, anti-convulsant, anti-tumor drugs. Quinazoline -2, 4-diketone derivatives have excellent biological activity, has been widely used in the field of pesticide and medicine, such as sterilization, herbicide, insecticidal, anticonvulsant and neuroprotective activity. Among them, 6-substituted -2, 4-quinazolinediones can be used as drugs anti-HIV, protein tyrosine kinase inhibitors, etc., and can also be used as pesticides because of their wide range of biological activities, such as pesticides and fungicides.

preparation

with O-aminobromobenzoic acid as the starting material, one-pot synthesis of 6-bromoquinazoline-2, 4-dione target compound [1] was investigated. The reaction scheme is shown in the figure below: Fig. 1 6-Bromo quinazolin-2, 4-dione reaction main instruments and reagent instruments: Electronic analytical balance, thermometer, magnetic stirrer, KDM type temperature control electric heating sleeve, iron Stand and clamp, round-bottom flask, suction filter funnel, spherical condenser, Beaker, vacuum drying oven, circulating water type vacuum pump, rotary evaporator, nuclear magnetic resonance instrument (AVANCE III HD 400 MHz). Reagents: 2-amino-5-bromobenzoic acid, potassium cyanate, glacial acetic acid, sodium hydroxide, concentrated hydrochloric acid, etc., reagents are analytically pure.

Last Update：2024-04-09 02:00:12