6-CHLOROPYRIDIN-3-YL-3-BORONIC ACID - Names and Identifiers
6-CHLOROPYRIDIN-3-YL-3-BORONIC ACID - Physico-chemical Properties
Molecular Formula | C5H5BClNO2
|
Molar Mass | 157.36 |
Density | 1.41±0.1 g/cm3(Predicted) |
Melting Point | 165°C(lit.) |
Boling Point | 336.9±52.0 °C(Predicted) |
Flash Point | 157.5°C |
Vapor Presure | 4.27E-05mmHg at 25°C |
Appearance | Bright yellow crystalline powder |
BRN | 9119810 |
pKa | 6.70±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.559 |
MDL | MFCD03094998 |
6-CHLOROPYRIDIN-3-YL-3-BORONIC ACID - Risk and Safety
Hazard Symbols | Xi - Irritant
![Irritant](//res.chembk.com/assets/images/hs/Xi.gif)
|
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 - Wear suitable protective clothing and gloves.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
|
WGK Germany | 3 |
HS Code | 29349990 |
Hazard Class | IRRITANT |
6-CHLOROPYRIDIN-3-YL-3-BORONIC ACID - Introduction
6-Chloropyridine-3-boronic acid is an organic compound with the chemical formula C5H4BClNO2. The following is a description of its nature, use, preparation and safety information:
Nature:
6-Chloropyridine-3-boronic acid is a white or light yellow crystal with a high melting point (about 183-185 degrees Celsius). It is stable at room temperature, but may decompose at high temperatures. It is slightly soluble in water and soluble in organic solvents such as ethanol, dimethyl ether, etc. Its chemical properties are relatively stable, and it is an important organic boron reagent.
Use:
6-Chloropyridine-3-boronic acid is an important intermediate in organic synthesis. It is often used to construct boron-containing compounds, such as for the synthesis of boron-containing compounds such as pyridine and benzothiophene, and is mainly used in the fields of drugs and materials. In addition, it is also widely used in metal-organic framework (MOF) materials and green catalysis.
Preparation Method:
6-Chloropyridine-3-boronic acid has many preparation methods, and the commonly used method is to react 6-chloropyridine with boric acid. Specifically, 6-chloropyridine can be reacted with triphenylboron or allyl borate under the catalysis of an oxidizing agent to obtain the product. The choice of reaction conditions and catalyst depends on the specific experimental requirements.
Safety Information:
6-Chloropyridine-3-boronic acid is irritating and may cause inflammation when in contact with skin and eyes. During use and preparation, care should be taken to avoid direct contact. Wear personal protective equipment, such as gloves, glasses and outside laboratory protective equipment. It should be operated in a well-ventilated place to avoid inhaling its vapors. When stored, it should be placed in a dry, cool, ventilated place, and stored in isolation from flammable and oxidizable substances. Disposal of waste shall be carried out in accordance with local regulations and hazardous waste disposal practices.
Last Update:2024-04-09 20:52:54