6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid
Chelidamic acid
CAS: 138-60-3
Molecular Formula: C7H5NO5
6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid - Names and Identifiers
| Name | Chelidamic acid |
| Synonyms | AKOS 90653 Chelidamic aicd Chelidamic acid Chelidamic acid AldrichCPR 4-PYRIDONE-2,6-DICARBOXYLIC ACID 4-HYDROXYPYRIDINE-2,6-DICARBOXYLIC ACID 4-Hydroxypyridine-2,6-dicarboxylic acid 4-HYDROXY-2,6-PYRIDINEDICARBOXYLIC ACID 6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate 1,4-DIHYDRO-4-OXO-2,6-PYRIDINEDICARBOXYLIC ACID 1,4-Dihydro-4-oxopyridine-2,6-dicarboxylic acid 4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid 2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo- (8CI)(9CI) |
| CAS | 138-60-3 |
| EINECS | 205-335-8 |
| InChI | InChI=1/C7H5NO5/c9-3-1-4(6(10)11)8-5(2-3)7(12)13/h1-2H,(H,8,9)(H,10,11)(H,12,13)/p-2 |
| InChIKey | XTLJJHGQACAZMS-UHFFFAOYSA-N |
6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid - Physico-chemical Properties
| Molecular Formula | C7H5NO5 |
| Molar Mass | 183.12 |
| Density | 1.726±0.06 g/cm3(Predicted) |
| Melting Point | 265-270 °C |
| Boling Point | 428.3±45.0 °C(Predicted) |
| Flash Point | 212.8°C |
| Vapor Presure | 1.56E-08mmHg at 25°C |
| Appearance | powder |
| Color | brown |
| BRN | 476229 |
| pKa | 0.12±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| In vitro study | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K i of 33 μM. |
6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29333990 |
6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid - Nature
| melting point | 263°C |
| storage conditions | Sealed in dry,Room Temperature |
| morphology | Crystalline Powder |
| color | Slightly yellow to yellow |
Last Update：2024-04-09 20:52:54
6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid - Reference Information
| biological activity | Chelidamic acid is a heterocyclic organic acid containing pyran skeleton, which has good coordination ability with metal ions. Chelidamic acid is also one of the most effective inhibitors of glutamate decarboxylase (glutamate decarboxylase), with a Ki value of 33 μM. |
| target | Ki: 33 μM (Glutamate decarboxylase). |
| Use | Hedyl is considered to be one of the most effective "conformational restrictive glutamic acid analogs" of glutamic acid decarboxylase. |
Last Update：2024-04-09 15:16:47
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