6-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline - Names and Identifiers
Name | 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
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Synonyms | 3-Amino-4-chlorobenzeneboronic acid 3-Amino-4-chlorophenylboronic acid, pinacol ester 3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER (3-AMINO-4-CHLORO)BENZENEBORONIC ACID, PINACOL ESTER 2-chloro-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) 2-Chloro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 6-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
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CAS | 850567-56-5
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InChI | InChI=1/C12H17BClNO2/c1-11(2)12(3,4)17-13(16-11)8-5-6-9(14)10(15)7-8/h5-7H,15H2,1-4H3 |
6-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline - Physico-chemical Properties
Molecular Formula | C12H17BClNO2
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Molar Mass | 253.53 |
Density | 1.15g/cm3 |
Melting Point | 142-144 |
Boling Point | 361.5°C at 760 mmHg |
Flash Point | 172.4°C |
Vapor Presure | 2.06E-05mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.53 |
6-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline - Risk and Safety
Hazard Symbols | Xi - Irritant
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Hazard Note | Irritant |
6-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline - Introduction
2-choro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, also known as 2-choro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, is an organic compound. The following is its nature, use, preparation and safety information:
Nature:
-Appearance: It is a solid, common white crystalline powder.
-Molecular formula: C15H19BClN2O3
-Molecular weight: 316.59g/mol
-melting point: about 120-125 ℃
-Solubility: It has good solubility in organic solvents, such as ethers, chlorinated hydrocarbons and alcohols.
Use:
-Chemical reagent: It can be used as an intermediate and catalyst in organic synthesis.
-Fluorescent dye: It can be used as a fluorescent probe and is widely used in cell imaging and fluorescence detection in biomedical and life science research.
-Dye synthesis: It can be used as a raw material for the synthesis of organic dyes.
Preparation Method:
The preparation method of 2-choro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is mainly carried out through the reaction sequence. The following is a common preparation method:
1. Reaction 1: First, 4-amino -2,6-dimethylphenol is reacted with boric acid and triethylamine to generate 4-amino -2,6-dimethylphenylboronic acid triethylamine salt.
2. Reaction 2: The salt obtained in Reaction 1 is then reacted with 2-chloro-5-(4,4,5,5-tetramethyl-1,3, 2-dioxolan-2-yl) aniline to produce the target product 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline.
Safety Information:
2-choro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline does not currently have clear safety data, so it should be handled and used in accordance with general laboratory safety practices. This compound may be irritating to the skin, eyes and respiratory tract, so avoid contact with skin and eyes, and avoid inhalation of gases or inhalation of dust. It is best to conduct a toxicity and safety assessment before use, and take appropriate safety measures, such as wearing appropriate personal protective equipment (such as gloves, goggles and protective masks). In the event of an accident, seek medical attention immediately and provide detailed information on the compound.
Last Update:2024-04-10 22:29:15