6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Names and Identifiers

Name	trichlormethiazide
Synonyms	Achletin trichlormethiazide Trichloromethiazide 6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid 6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide 6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
CAS	133-67-5
EINECS	205-118-8
InChI	InChI=1/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Physico-chemical Properties

Molecular Formula	C8H8Cl3N3O4S2
Molar Mass	380.66
Density	1.748
Melting Point	248-250℃
Boling Point	631.3±65.0 °C(Predicted)
Flash Point	335.6°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	7.62E-16mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Merck	14,9624
pKa	pKa 6.9(acetone/H2O) (Uncertain)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.6000 (estimate)
Use	Used as a diuretic

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	42/43 - May cause sensitization by inhalation and skin contact.
Safety Description	36 - Wear suitable protective clothing.
WGK Germany	2
RTECS	DK8925000
HS Code	2935904000
Toxicity	LD50 orally in rats: >20000 mg/kg (Goldenthal)

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Reference Information

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
biological activity	Trichlormethiazide is a diuretic with similar characteristics to Hydrochlorothiazide.
Animal Model:	Male Sprague-Dawley rats (350-450 g)
Dosage:	10 mg/kg
Administration:	Intravenous injection, daily, for 15 days
Result:	Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake.
use	diuretics.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 21:21:28

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide

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CAS: 133-67-5
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　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

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6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide

trichlormethiazide

CAS: 133-67-5

Molecular Formula: C8H8Cl3N3O4S2

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Names and Identifiers

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Physico-chemical Properties

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Risk and Safety

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Reference Information

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6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide Request for Quotation

trichlormethiazide

CAS: 133-67-5

Molecular Formula: C8H8Cl3N3O4S2

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Names and Identifiers

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Physico-chemical Properties

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Risk and Safety

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide - Reference Information

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6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide