6-Chloro-4-fluoro-1H-indole

6-Chloro-4-fluoro-1H-indole - Names and Identifiers

Name	6-Chloro-4-fluoro-1H-indole
Synonyms	6-Chloro-4-fluoro-1H-indole 1H-Indole, 6-chloro-4-fluoro-
CAS	885520-88-7
InChI	InChI=1S/C8H5ClFN/c9-5-3-7(10)6-1-2-11-8(6)4-5/h1-4,11H

6-Chloro-4-fluoro-1H-indole - Physico-chemical Properties

Molecular Formula	C8H5ClFN
Molar Mass	169.58
Density	1.436±0.06 g/cm3(Predicted)
Boling Point	289.5±20.0 °C(Predicted)
pKa	15.50±0.30(Predicted)
Storage Condition	2-8°C

6-Chloro-4-fluoro-1H-indole - Introduction

It is an organic compound with the chemical formula C8H4ClFN. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless or light yellow crystal
-Melting point: 89-91 degrees Celsius
-Boiling point: 337 degrees Celsius
-Density: 1.53g/cm3
-Solubility: Soluble in organic solvents, such as ethanol and chlorinated hydrocarbons

Use:
It has a wide range of applications in organic synthesis.
-It can be used as a pharmaceutical intermediate for the synthesis of compounds with anti-tumor, anti-viral and anti-infective activities.
-It can also be used to synthesize organic materials containing indole structures, such as fluorescent dyes, photosensitizers and organic photoelectric materials.

Preparation Method:
There are many preparation methods for phosphonium. One commonly used method is to obtain by the reaction of fluorinated and chlorinated aromatic compounds.
-First, fluorinate p-chlorophenol under acidic conditions to obtain p-fluorophenol.
-Then, p-fluorophenol is reacted with indole, and chlorination reaction is carried out in the presence of a catalyst to obtain phosphonium.

Safety Information:
As with any chemical, pay attention to safety when using it.
-Avoid inhaling its dust and avoid contact with skin and eyes.
-Use should follow good laboratory practices, such as wearing chemical protective gloves and glasses.
-In case of ingestion or skin contact, rinse immediately with water and seek medical help.
-When storing, it should be stored in a sealed container, away from heat sources and flames.

This information provides an overview of the compound, but please note that the specific use and handling conditions should be based on actual needs and laboratory guidance.

Last Update：2024-04-09 21:01:54