6-Chloro-5-fluoropyridin-3-ol

6-Chloro-5-fluoropyridin-3-ol - Names and Identifiers

Name	6-Chloro-5-fluoropyridin-3-ol
Synonyms	6-Chloro-5-fluoropyridin-3-ol 3-Pyridinol,6-chloro-5-fluoro- 3-pyridinol, 6-chloro-5-fluoro- 2-Chloro-3-fluoro-5-hydroxypyridine 2-CHLORO-3-FLUORO-5-HYDROXYPYRIDINE(RS20015747)
CAS	870062-76-3
InChI	InChI=1/C5H3ClFNO/c6-5-4(7)1-3(9)2-8-5/h1-2,9H

6-Chloro-5-fluoropyridin-3-ol - Physico-chemical Properties

Molecular Formula	C5H3ClFNO
Molar Mass	147.53
Density	1.517
Boling Point	347.0±37.0 °C(Predicted)
Flash Point	163.7°C
Vapor Presure	2.76E-05mmHg at 25°C
pKa	7.92±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.552

6-Chloro-5-fluoropyridin-3-ol - Introduction

It is an organic compound with the chemical formula C5H3ClFNO. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: It is a colorless or yellowish solid.
-Solubility: It is not very soluble in water and is soluble in some common organic solvents, such as ethanol and ether.
-Melting point: Its melting point is about 85-89°C.

Use:
-is an important intermediate compound that can be used to synthesize other organic compounds. It can be used as a raw material or reagent in organic synthesis for the synthesis of drugs, pesticides, dyes and other compounds.

Preparation Method: There are different ways to prepare
-, and the following is one of the commonly used methods:
1.5-chloro -3-fluoropyridine reacts with sodium hydroxide to generate 5-chloro -3-fluoropyridine alcohol.
2. In the presence of a catalyst, react 5-chloro-3-fluoropyridine alcohol with thionyl chloride to obtain pyridine.

Safety Information:
-has a certain toxicity, need to pay attention to safe operation and protective measures.
-Appropriate protective equipment, such as lab gloves, safety goggles and protective clothing, must be worn during use.
-Avoid direct contact with skin, eyes and mucous membranes, and avoid breathing gas or dust.
-When operating with the compound, it should be carried out under well-ventilated laboratory conditions and follow the correct operating procedures and safety regulations.
-When used as a synthetic intermediate, it should be used under the guidance of professionals, and pay attention to the correct storage and handling methods.
-Regarding the use and handling of thionyl chloride, it is also necessary to follow the corresponding safety guidelines.

Last Update：2024-04-09 19:05:52