6-Chloro-m-anisidine

6-Chloro-m-anisidine - Names and Identifiers

Name	6-Chloro-m-anisidine
Synonyms	2-Chloro-5-methoxyan 6-Chloro-m-anisidine Iguratimod Impurity 9 3-Amino-4-chloroanisole 6-chloro-meta-anisidine 2-Chloro-5-methoxyaniline 2-Chloro-5-methoxybenzenamine 1-Amino-2-chloro-5-methoxybenzene 2-chloro-5-MethoxybenzenaMine hydrochloride 3-Amino-4-chloroanisole, 6-Chloro-m-anisidine 3-Amino-4-chloroanisole [2-Chloro-5-methoxyaniline]
CAS	2401-24-3
EINECS	219-277-6
InChI	InChI=1/C7H8ClNO.ClH/c1-10-5-2-3-6(8)7(9)4-5;/h2-4H,9H2,1H3;1H

6-Chloro-m-anisidine - Physico-chemical Properties

Molecular Formula	C7H8ClNO
Molar Mass	157.6
Density	1.261 g/mL at 25 °C
Melting Point	207°C (dec.)(lit.)
Boling Point	135-137°C 12mm
Flash Point	135-137°C/12mm
Water Solubility	Slightly soluble in water.
Vapor Presure	0.0168mmHg at 25°C
BRN	2082193
pKa	2.23±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.5848
Physical and Chemical Properties	Melting point 207°C (dec.)(lit.) boiling point 135-137 ° C. 12mm refractive index 1.5848 flash point 135-137 ° C./12mm BRN 2082193

6-Chloro-m-anisidine - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	2811
WGK Germany	3
Hazard Class	6.1
Packing Group	III

6-Chloro-m-anisidine - Introduction

6-Chloro-m-anisidine, also known as 6-Chloro-m-anisidine, has the chemical formula C7H8ClNO. The following is a description of its nature, use, preparation and safety information:

Nature:
6-Chloro-m-anisidine is an organic compound that appears as a white to light yellow solid. It can react with oxygen in the air at room temperature and is easy to oxidize and change color. It is soluble in ethanol, ether and chloroform and slightly soluble in water. Its melting point is at 39-41°C.

Use:
6-Chloro-m-anisidine is an important intermediate compound, which is widely used in the fields of pesticide, dye and medicine. For example, it can be used for the synthesis of the anti-tuberculosis drug etherfloxacin; It can also be used as a dye intermediate for the synthesis of aniline dyes, such as the positive dyes Pap Red and Pap Brown.

Method:
6-Chloro-m-anisidine can be prepared by the reaction of 2-methoxyaniline with dichloromethane by adding Chloroacetyl Chloride. In the reaction, methylene chloride and Chloroacetyl Chloride react to form a formylation reagent, which is then reacted with 2-methoxyaniline to form the target product 6-Chloro-m-anisidine.

Safety Information:
6-Chloro-m-anisidine is a toxic compound that is irritating and corrosive. Exposure to it may cause irritation of the eyes, skin and respiratory tract. Personal protective equipment, such as glasses and gloves, should be worn during operation. Avoid breathing its vapors and make sure to operate in a well-ventilated area. Such as accidental contact or inhalation, should immediately wash the affected area, and immediately seek medical treatment.

Last Update：2024-04-09 02:00:44