6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline - Names and Identifiers

Name	6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline
Synonyms	BUTTPARK 374-03 6-fluoro-2-(trifluoromethyl)-4-quinolone 6-Fluoro-2-(trifluoromethyl)quinolin-4-ol 6-fluoro-2-(trifluoromethyl)quinolin-4-ol 4-Quinolinol, 6-fluoro-2-(trifluoromethyl)- 6-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one 6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline dichloro(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)methylsilane
CAS	31009-34-4
InChI	InChI=1/C11H7Cl2F17Si/c1-31(12,13)3-2-4(14,15)5(16,17)6(18,19)7(20,21)8(22,23)9(24,25)10(26,27)11(28,29)30/h2-3H2,1H3

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline - Physico-chemical Properties

Molecular Formula	C10H5F4NO
Molar Mass	231.15
Density	1.511±0.06 g/cm3(Predicted)
Melting Point	259-263°C
Boling Point	302.9±37.0 °C(Predicted)
Flash Point	101.4°C
Vapor Presure	0.0482mmHg at 25°C
pKa	6.40±0.40(Predicted)
Storage Condition	2-8℃
Refractive Index	1.33
MDL	MFCD00276582

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGIII
HS Code	29334900
Hazard Note	Irritant

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline - Introduction

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is an organic compound with the chemical formula C11H6F4NO. The following is a description of its nature, use, preparation and safety information:

Nature:
6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is a solid, white crystalline at room temperature. It has a density of 1.54g/cm3 and a melting point of 125-128°C. The compound is stable under regular conditions and is soluble in some organic solvents such as chloroform and dichloromethane.

Use:
6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline has a wide range of uses in the field of pharmaceutical research. It is often used as an intermediate for the synthesis of other organic compounds or drugs. In addition, the compound can also be used as a catalyst for the preparation of fluorescent probes and organic synthesis reactions.

Method:
The preparation method of 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline mainly includes a two-step reaction. First, 2-chloro-6-fluoro-4-hydroxyquinoline is formed by the reaction of chlorination and nitrite, followed by the reaction of carbon monoxide and trifluoromethyllithium to form the final product.

Safety Information:
Data on the specific toxicity and danger of this compound are relatively limited. However, like other chemicals, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline also needs to be used and handled under appropriate conditions. In the process of use, must comply with the chemical safety procedures, such as wearing protective gloves, goggles and protective clothing, and ensure that the operation in a well-ventilated place. During handling and storage, care should be taken to avoid contact with strong oxidants and combustibles.

In addition, for personal and public safety considerations, any chemical should be carefully read and operated in accordance with relevant safety data sheets and operating instructions before use.

Last Update：2024-04-09 21:54:55