6-Fluoroquinaldine
6-fluoro-2-methylquinoline
CAS: 1128-61-6
Molecular Formula: C10H8FN
6-Fluoroquinaldine - Names and Identifiers
| Name | 6-fluoro-2-methylquinoline |
| Synonyms | AKOS 1002 6-FLUOROQUINALDINE 6-Fluoroquinaldine 6-FLUORO-2-METHYLQUINOLINE 2-METHYL-6-FLUOROQUINOLINE 7-fluoro-2-methylquinoline 6-fluoro-2-methylquinoline 6-Fluoro-2-methyl-1-azanaphthalene |
| CAS | 1128-61-6 |
| EINECS | 214-439-2 |
| InChI | InChI=1/C10H8FN/c1-7-2-3-8-4-5-9(11)6-10(8)12-7/h2-6H,1H3 |
6-Fluoroquinaldine - Physico-chemical Properties
| Molecular Formula | C10H8FN |
| Molar Mass | 161.18 |
| Density | 1.1465 (estimate) |
| Melting Point | 49-53 °C (lit.) |
| Boling Point | 99 °C / 3mmHg |
| Flash Point | >230°F |
| Solubility | Soluble in Chloroform. |
| Vapor Presure | 0.0456mmHg at 25°C |
| Appearance | Yellow to brown crystals |
| Color | White to Almost white |
| BRN | 1281677 |
| pKa | 5.16±0.43(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6 |
| MDL | MFCD00041233 |
| Physical and Chemical Properties | Melting Point: 50 - 54 |
6-Fluoroquinaldine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R38 - Irritating to the skin R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29334990 |
| Hazard Note | Irritant |
6-Fluoroquinaldine - Reference Information
| Introduction | 6-fluoro-2-methylquinoline is a quinoline derivative. Quinoline derivatives are a class of compounds with bactericidal, antibacterial, antihypertensive, antidepressant, anti-allergic, anti-malarial, anti-tumor and anti-cancer biological and pharmacological activities. Many quinoline derivatives with these pharmacological activities are extracted from natural products, such as quinine, camptothecin and a substance with a chemical name of Miloxacin. |
| preparation | accurately weigh 0.005mmol(1.1mg) transition metal, add 10mL into young's reaction tube with magnetic stirrer, and replace the young's reaction tube with oxygen to make the reaction proceed under oxygen conditions, the Young's reaction tube was accurately added with 0.04mmol of auxiliary catalyst I, 0.08mmol of auxiliary catalyst II, 0.2 mmol4-fluoroaniline and 1ml of absolute ethanol with a syringe, placed on a magnetic stirrer, and stirred at 150 ℃ for 18 hours. After the reaction is over, the pH of the reaction solution is adjusted to be neutral, and the reaction solution is post-treated to obtain a pure product of 6-fluoro-2-methylquinoline with a yield of 75%. |
Last Update：2024-04-10 22:29:15
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