Name | 6-Fluoro-1-indanone |
Synonyms | 6-fluro-indanone 6-FLUOROINDANONE 6-Fluoro-1-indenone 6-Fluoro-1-indanone 6-Fluoro-indan-1-on 6-FLURORO-1-INDANONE 6-Fluroro-1-Indanone 6-FLUORO-2,3-DIHYDROINDEN-1-ONE 6-Fluoro-2,3-dihydro-1H-inden-1-one 6-fluoro-2,3-dihydro-1H-inden-1-one 1H-Inden-1-one, 6-fluoro-2,3-dihydro- |
CAS | 1481-32-9 |
EINECS | 625-201-6 |
InChI | InChI:1S/C9H7FO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2 |
InChIKey | LVUUCFIQQHEFEJ-UHFFFAOYSA-N |
Molecular Formula | C9H7FO |
Molar Mass | 150.15 |
Density | 1.259±0.06 g/cm3(Predicted) |
Melting Point | 56-60 °C |
Boling Point | 60 °C |
Flash Point | 60°C/0.5mm |
Solubility | soluble in Methanol |
Appearance | White to light yellow crystal powder |
Color | Off-white to pale brown |
BRN | 1448695 |
Storage Condition | Sealed in dry,Room Temperature |
MDL | MFCD01318147 |
Physical and Chemical Properties | Off-white crystals. Melting point 60-62 °c. |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
WGK Germany | 2 |
HS Code | 29147000 |
Hazard Class | IRRITANT |
Uses | 6-fluoro-1-indanone can be used as an intermediate in pharmaceutical synthesis. It can be used as a raw material to prepare 3-(4-Fluorophenyl) propionic acid, and then the Friedel-Crafts reaction is closed loop to generate 6-fluoro-1-indanone. |
preparation | step 1: suspend p-fluorocinnamic acid (1 equivalent) and PtO2(2.2mol%) in ethanol (EtOH)(8ml/mmol cinnamic acid), vigorously stir (1bar) in H2 atmosphere until the reaction mixture no longer absorbs H2, filter the suspension and wash the residue with EtOH, the solvent of the filtrate was removed by vacuum, the resulting crude mixture of propionic acid and propionate was dissolved in EtOH(2ml/mmol), and then an aqueous NaOH solution (relative to 2.5 equivalents) was added. The solution was stirred for 16 hours and the volume of the mixture was reduced by applying a vacuum. Dilute the resulting solution with water and acidify with an aqueous solution of 2NHCl. The suspension was filtered and the residue was washed with water to give 3-(4-fluorophenyl) propionic acid. Step 2: Oxalyl chloride (3.40 equivalents) is carefully added to a solution of 3-(4-fluorophenyl) propionic acid (1 equivalent) CH2Cl2(1.4ml/mmol propionic acid) and DMF(0.01ml/mmol propionic acid) to foam the solution. The resulting clarified solution was stirred for a further 6 hours, followed by vacuum removal of volatile components. At 0°C, the solution in CH2Cl2 of the acid chloride (1.2ml/mmol of propionic acid) was added dropwise to the solution of AlCl3(1.30 equivalents) in CH2Cl2(0.75ml/mmolAlCl3). After the addition, the ice bath was removed and heated under reflux for another 3 hours, the mixture was poured into ice water, and the aqueous phase was extracted with CH2Cl2, the combined organic phase was dried and filtered with Na2SO4, and the solvent was removed in vacuum. The crude product was purified by column chromatography to obtain 6-fluoro-1-indanone. |