6-Hydroxy-2-Phenyl-3(2H)-Pyridaxinone
3-HYDROXY-1-PHENYL-6-PYRIDAZONE
CAS: 1698-54-0
Molecular Formula: C10H8N2O2
6-Hydroxy-2-Phenyl-3(2H)-Pyridaxinone - Names and Identifiers
6-Hydroxy-2-Phenyl-3(2H)-Pyridaxinone - Physico-chemical Properties
| Molecular Formula | C10H8N2O2 |
| Molar Mass | 188.18 |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | 6-Hydroxy-2-phenyl-3-pyridone is a white powder crystal, m.p.268 ~ 272 ℃, easily soluble in dimethylformamide and 1-methyl-2-pyrrolidone, hardly soluble in water, Methanol, benzene, can form corresponding salts with various alkaline substances, is stable in acidic, neutral, and alkaline solutions, and decomposes when encountering strong oxidants. |
6-Hydroxy-2-Phenyl-3(2H)-Pyridaxinone - References
| preparation | the preparation method is the condensation of phenylhydrazine with maleic anhydride, 6-hydroxy-2-phenyl-3-pyridone was obtained. Phenylhydrazine hydrochloride was dissolved in water, stirred and heated to 95 ℃, maleic anhydride was added at a time, refluxed for 2H, cooled to precipitate light yellow solid, filtered and washed with water, and the filter cake was dissolved with hot 10% sodium carbonate solution, after filtration and washing with water until the washing solution was free of chloride ions, the filter cake was dried to obtain 6-hydroxy-2-phenyl-3-pyridone. |
| Use | 6-hydroxy-2-phenyl-3-pyridone is an intermediate of The organophosphorus insecticide, benzopyridazine thiophosphate. |
| production method | It is obtained from the cyclization of phenylhydrazine or phenylhydrazine sulfate, phenylhydrazine hydrochloride and maleic anhydride. Slowly add hydrochloric acid in phenylhydrazine solution, while maintaining the negative pressure of 40mm Hg, add maleic anhydride at 95 ℃ or more, reflux for 4H, cool and filter, wash with water until neutral, the content of more than 97% of the finished product. Another operation method is to add 6% phenylhydrazine sulfate aqueous solution to the glass reaction pot, add maleic anhydride under stirring, and raise the temperature to 106-108 ℃, the temperature was maintained for 4H (at the end of the reaction, phenylhydrazine in the reaction solution was less than 0.1). It was cooled to room temperature, filtered, washed and dried to give 6-hydroxy-2-phenyl-3-pyridone. The content and yield (based on phenylhydrazine) were all above 92%. |
Last Update：2024-04-09 02:00:14
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CAS: 1698-54-0
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CAS: 1698-54-0
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