6-Hydroxy-2-methyl-5-nitro-4(1H)-pyrimidinone - Names and Identifiers
6-Hydroxy-2-methyl-5-nitro-4(1H)-pyrimidinone - Physico-chemical Properties
| Molecular Formula | C5H5N3O4
|
| Molar Mass | 171.11 |
| Density | 1.84 |
| Melting Point | 270-280℃ |
| pKa | 1.71±0.10(Predicted) |
6-Hydroxy-2-methyl-5-nitro-4(1H)-pyrimidinone - Introduction
6-DIOL is a chemical substance with the molecular formula C6H6N4O4 and a relative molecular mass of 198.14. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 6-DIOL is a colorless crystalline powder.
-Solubility: It is soluble in water, alcohols and some organic solvents.
-Melting point: About 220-224 degrees Celsius.
-Stability: The compound is relatively stable at room temperature.
Use:
-Chemical reagents: 6-DIOL can be used as organic synthesis intermediates and chemical reagents, and has a wide range of applications in the field of organic chemistry and medicine.
-Drug synthesis: It can be used to synthesize a variety of drugs, including antibiotics, anti-cancer drugs and antiviral drugs.
Method:
The preparation of 6-DIOL can usually be carried out by the following steps:
1. First, 2-acetyl-5-nitro-4,6-pyrimidine (2-acetyl-5-nitro-4,6-dimethylpyrimidine) was reacted with NaOH to give 2-acetomethyl-5-nitro-4, 6-pyrimidine (2-acetyl-5-nitro-4,6-dimethyl-1,3-diazine).
2. Then, reduce it to 6-DIOL, and use a reducing agent (such as Sodium phosphite or sodium sulfite) for reaction.
Safety Information:
-, 6-DIOL is usually relatively safe under normal use conditions, but as a chemical substance, you still need to pay attention to the following:
-Avoid inhalation or contact with skin and eyes.
-Appropriate personal protective equipment should be used during use, such as laboratory gloves and protective glasses.
-The compound should be handled in a well-ventilated area.
-should be stored in a dry, cool and ventilated place, and away from fire and flammable materials.
-When exposed to the compound, rinse with plenty of water and seek medical advice.
Last Update：2024-04-09 21:01:54