Molecular Formula | C9H8N2O3 |
Molar Mass | 192.17 |
Density | 1.47±0.1 g/cm3(Predicted) |
Melting Point | >255oC (dec.) |
Boling Point | 420.0±55.0 °C(Predicted) |
Solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
Appearance | Solid |
Color | Light Beige |
pKa | 8.07±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Introduction | 6-methoxy-7-hydroxyquinazolin-4-one is a pharmaceutical intermediate used to prepare gefitinib. Gefitinib (Gefitinib), whose chemical name is 4-(3-chloro-4-fluoroanilino) -7-methoxy-6-(3-morpholinyl propoxy) quinazoline, is a protein tyrosine kinase inhibitor developed by AstraZeneca (AstraZeneca). |
Uses | 6-methoxy-7-hydroxyquinazolin-4-one is a ketone organic substance and can be used as a pharmaceutical intermediate. |
preparation | weigh 1mmol of 2-iodine (bromine)-4-methoxy -5-hydroxybenzonitrile, 1.5mmol of formamidine hydrochloride in 10mL of aqueous phase, add 0.1mmol of CuI catalyst, alkali K2CO33mmol, microwave heating and reflux at 80 ℃ for 0.5h, and microwave power 150W. After the reaction, cool to room temperature and filter to obtain solid powder. |