6-Methoxy-7-Hydroxyquinazolin-4-One

Name	6-Methoxy-7-Hydroxyquinazolin-4-One
Synonyms	7-Hydroxy-6-Methoxy-3,4-d... 6-METHOXY-7-HYDROXYQUINAZOLIN-4-ONE 6-Methoxy-7-Hydroxyquinazolin-4-One 6-Methoxy-7-Hydroxyquinazoline-4-One 6-methoxy-7-hydydroxyquinazoline-4-one 7-hydroxy-6-methoxyquinazolin-4(1H)-one 7-hydroxy-6-methoxy-4(3H)-Quinazolinone 7-Hydroxy-6-methoxy-3H-quinazolin-4-one 7-Hydroxy-6-Methoxy-3,4-dihydroquinazolin-4-one
CAS	162012-72-8

Molecular Formula	C9H8N2O3
Molar Mass	192.17
Density	1.47±0.1 g/cm3(Predicted)
Melting Point	>255oC (dec.)
Boling Point	420.0±55.0 °C(Predicted)
Solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Appearance	Solid
Color	Light Beige
pKa	8.07±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature

Introduction	6-methoxy-7-hydroxyquinazolin-4-one is a pharmaceutical intermediate used to prepare gefitinib. Gefitinib (Gefitinib), whose chemical name is 4-(3-chloro-4-fluoroanilino) -7-methoxy-6-(3-morpholinyl propoxy) quinazoline, is a protein tyrosine kinase inhibitor developed by AstraZeneca (AstraZeneca).
Uses	6-methoxy-7-hydroxyquinazolin-4-one is a ketone organic substance and can be used as a pharmaceutical intermediate.
preparation	weigh 1mmol of 2-iodine (bromine)-4-methoxy -5-hydroxybenzonitrile, 1.5mmol of formamidine hydrochloride in 10mL of aqueous phase, add 0.1mmol of CuI catalyst, alkali K2CO33mmol, microwave heating and reflux at 80 ℃ for 0.5h, and microwave power 150W. After the reaction, cool to room temperature and filter to obtain solid powder.

Last Update：2024-04-09 20:49:11

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CAS: 162012-72-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: 6-METHOXY-7-HYDROXYQUINAZOLIN-4-ONE Visit Supplier Webpage Request for quotation
CAS: 162012-72-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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6-Methoxy-7-Hydroxyquinazolin-4-One

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