6-Nitro-m-anisicacid
5-Methoxy-2-nitrobenzoic acid
CAS: 1882-69-5
Molecular Formula: C8H7NO5
6-Nitro-m-anisicacid - Names and Identifiers
| Name | 5-Methoxy-2-nitrobenzoic acid |
| Synonyms | 6-Nitro-m-anisicacid 5-methoxy-2-nitrobenzoate 5-Methoxy-nitrobenzoic Acid 2-nitro-5-methoxybenzoic acid 5-Methoxy-2-nitrobenzoic acid 5-METHOXY-2-NITROBENZOIC ACID 6-Nitro-m-anisic acid, 2-Carboxy-4-methoxyn 6-Nitro-m-anisic acid, 2-Carboxy-4-methoxynitrobenzene |
| CAS | 1882-69-5 |
| InChI | InChI=1/C8H7NO5/c1-14-5-2-3-7(9(12)13)6(4-5)8(10)11/h2-4H,1H3,(H,10,11)/p-1 |
| InChIKey | URADKXVAIGMTEG-UHFFFAOYSA-N |
6-Nitro-m-anisicacid - Physico-chemical Properties
| Molecular Formula | C8H7NO5 |
| Molar Mass | 197.14 |
| Density | 1.430 |
| Melting Point | 125-130 °C (lit.) |
| Boling Point | 334.23°C (rough estimate) |
| Flash Point | 195.5°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 4.17E-07mmHg at 25°C |
| Appearance | Granules |
| Color | Beige to gray or brown |
| BRN | 1877657 |
| pKa | 2.06±0.25(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5700 (estimate) |
| Physical and Chemical Properties | WGK Germany:3 |
6-Nitro-m-anisicacid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| HS Code | 29182900 |
6-Nitro-m-anisicacid - Reference Information
| Use | 5-methoxy-2-nitrobenzoic acid is used in the synthesis of Cathepsin S inhibitors with antitumor applications. In addition, a 2-amino comtrotastatin derivative with anti-mitotic effect was synthesized by using this compound. 5-methoxy-2-nitrobenzoic acid can also be used to synthesize betrixaban (1) under the chemical name N-(5-chloro-2-pyridyl)-2-[[4-[(dimethylamino) formamidino] benzoyl] amino]-5-methoxybenzamide, Portola, original company. |
| preparation | M-methoxybenzaldehyde is added in portions into nitric acid step by step, the internal temperature is controlled at 18-20 ℃, and the temperature is raised to room temperature after feeding, reaction for 10 minutes, vigorously stirred, the reaction solution poured into 1000ml of cold water, Suction filtration, solid with sodium hydroxide aqueous solution and the pH value of 12,40 deg C to add potassium permanganate, heat preservation reaction for 1 hour, hot Suction filtration, filtrate, dry. 5-methoxy-2-nitrobenzoic acid was obtained. |
Last Update：2024-04-09 21:01:54
