6-bromo-2-(trifluoromethyl)quinolin-4(1H)-one

6-bromo-2-(trifluoromethyl)quinolin-4(1H)-one - Names and Identifiers

Name	2-(trifluoromethyl)-4-quinolinol
Synonyms	NSC 232494 BUTTPARK 294-06 2-(TRIFLUOROMETHYL)-4-QUINOLINOL 2-(trifluoromethyl)quinolin-4-ol 2-(trifluoromethyl)-4-quinolinol 2-(TRIFLUOROMETHYL)QUINOLIN-4-OL 2-Trifluoromethyl-4-hydroxyquinoline 2-(trifluoromethyl)quinolin-4(1H)-one 4-Hydroxy-2-(trifluoromethyl)quinoline 4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 6-bromo-2-(trifluoromethyl)quinolin-4(1H)-one
CAS	1701-18-4
InChI	InChI=1/C10H6F3NO/c11-10(12,13)9-5-8(15)6-3-1-2-4-7(6)14-9/h1-5H,(H,14,15)

6-bromo-2-(trifluoromethyl)quinolin-4(1H)-one - Physico-chemical Properties

Molecular Formula	C10H6F3NO
Molar Mass	213.16
Density	1.433±0.06 g/cm3(Predicted)
Melting Point	209-211°C
Boling Point	299.1±35.0 °C(Predicted)
Flash Point	87.4°C
Vapor Presure	0.111mmHg at 25°C
pKa	6.62±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.516
MDL	MFCD00153196

6-bromo-2-(trifluoromethyl)quinolin-4(1H)-one - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN2811
Hazard Note	Irritant
Hazard Class	6.1
Packing Group	III

6-bromo-2-(trifluoromethyl)quinolin-4(1H)-one - Introduction

2-(trifluoromethyl)-4-quinolinol is an organic compound with the chemical formula C10H6F3NO. The following is an introduction to its nature, use, preparation and safety information:

Nature:
1. Appearance: 2-(trifluoromethyl)-4-quinolinol is a colorless to pale yellow crystal or powdery solid.
2. Melting Point: melting point of 50-52 degrees Celsius.
3. Solubility: its solubility in water is low, but it can be dissolved in most organic solvents such as alcohols, ethers and chlorinated hydrocarbons.

Use:
1. 2-(trifluoromethyl)-4-quinolinol, as an advanced organic synthesis intermediate, is widely used in the fields of medicine, pesticide and dye industry. It can be used in the synthesis of various drugs and pesticides (such as benzothiazole and trifluoromethyl pesticides).
2. It can also be used as a dye in the fluorescent whitening agent, nucleophilic reagent, coordination reagent, etc.

Method:
2-(trifluoromethyl)-4-quinolinol has various preparation methods, and common methods include the following:
1. The target product can be obtained by reacting 4-chloro-2-trifluoromethylquinoline with sodium hydroxide, and then dechlorination with alcohol.
2. The target product can also be obtained by the reaction of 2-cyano -4-chloroquinoline with trifluoromethane and hydrolysis.
The choice of preparation method depends on the specific experimental requirements and conditions.

Safety Information:
1. 2-(trifluoromethyl)-4-quinolinol is a chemical, and its use and operation should follow relevant safe operating procedures and personal protective measures.
2. In handling or use, should wear appropriate protective equipment, such as gloves, goggles and protective clothing.
3. Avoid contact with skin, eyes and respiratory tract. For accidental contact, rinse thoroughly with clean water and seek medical help.
4. Storage should be sealed, away from the fire and organic matter. Avoid contact with oxidants, acids and high temperatures.
5. If inhaled overdose or ingested, seek medical attention immediately and show the relevant information to the doctor.

Please note that when using and handling this chemical, you should follow relevant safety operating guidelines and strictly comply with local laws and regulations.

Last Update：2024-04-09 15:17:53