6-chloro-2-(trichloromethyl)-4H-chromen-4-one

6-chloro-2-(trichloromethyl)-4H-chromen-4-one - Names and Identifiers

Name	SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1)
Synonyms	ST034307 ST 034307 ST-034307 133406-29-8 6-chloro-2-(trichloromethyl)-4H-chromen-4-one 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-
CAS	133406-29-8

6-chloro-2-(trichloromethyl)-4H-chromen-4-one - Physico-chemical Properties

Molecular Formula	C10H4Cl4O2
Molar Mass	297.95
Density	1.674±0.06 g/cm3(Predicted)
Boling Point	329.1±42.0 °C(Predicted)
Solubility	Soluble in DMSO
Appearance	solid
Color	Yellow
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Use	ST034307 is an effective and selective adenylyl cyclase 1 inhibitor with an IC50 value of 2.3 μM.
In vitro study	ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca 2+ /calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.
In vivo study	ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E 50 ) value for analgesia of 0.28 μg in the mouse pain model.

6-chloro-2-(trichloromethyl)-4H-chromen-4-one - Reference

Reference

1: Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci Signal. 2017 Feb 21;10(467). pii: eaah5381. doi: 10.1126/scisignal.aah5381. PubMed PMID: 28223412.

6-chloro-2-(trichloromethyl)-4H-chromen-4-one - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.356 ml	16.781 ml	33.563 ml
5 mM	0.671 ml	3.356 ml	6.713 ml
10 mM	0.336 ml	1.678 ml	3.356 ml
5 mM	0.067 ml	0.336 ml	0.671 ml

Last Update：2024-01-02 23:10:35

6-chloro-2-(trichloromethyl)-4H-chromen-4-one - Introduction

SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1) is an organic compound with the chemical formula C10H10N4O. The following is about SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1) Properties, Uses, detailed description of legal and safety information:

Nature:
SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1) is a white solid, soluble in common organic solvents. It has a moderate melting and boiling point.

Use:
SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1) has a wide range of applications in the field of chemical research. It is often used as a reagent, Catalyst or ligand, and plays an important role in organic synthesis and natural product synthesis. In addition, it is also used for the preparation of specific organic materials.

Preparation Method:
SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1) can be prepared in various ways. The common method is to select appropriate starting materials according to specific chemical routes and reaction conditions through synthetic chemical reactions, and to carry out reaction, separation and purification to obtain the final product.

Safety Information:
When using SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1), some safety measures need to be taken. Since SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1) has not been widely studied and applied, its safety and environmental impact may be unclear. Therefore, when manipulating and processing SulfoniuM, (4-hydroxyphenyl)Methyl(1-naphthalenylMethyl)-, (OC-6-11)-hexafluoroantiMonate(1-) (1:1), it is necessary to wear appropriate personal protective equipment, avoid contact with skin and eyes, and ensure that the operation is carried out in a well-ventilated laboratory environment. Disposal of residues, wastes and contaminants shall be carried out and disposed of in accordance with local regulations.

Last Update：2024-04-10 22:29:15