6-chloro-3-nitropyridin-2(1H)-one

6-chloro-3-nitropyridin-2(1H)-one - Names and Identifiers

Name	6-chloro-3-nitropyridin-2(1H)-one
Synonyms	6-Chloro-3-nitropyridin-2-ol 2-pyridinol, 6-chloro-3-nitro- 6-Chloro-3-nitro-pyridine-2-one 2-hydroxy-3-nitro-6-cloropyridine 6-Chloro-3-nitro-2(1H)-pyridinone 6-chloro-3-nitropyridin-2(1H)-one 6-chloro-3-nitro-1H-pyridin-2-one 2-Hydroxy-3-Nitro-6-Chloropyridine
CAS	92138-35-7
InChI	InChI=1/C5H3ClN2O3/c6-4-2-1-3(8(10)11)5(9)7-4/h1-2H,(H,7,9)

6-chloro-3-nitropyridin-2(1H)-one - Physico-chemical Properties

Molecular Formula	C5H3ClN2O3
Molar Mass	174.54
Density	1.61±0.1 g/cm3(Predicted)
Boling Point	313.2±42.0 °C(Predicted)
Flash Point	143.2°C
Vapor Presure	0.000503mmHg at 25°C
pKa	3.68±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.602

6-chloro-3-nitropyridin-2(1H)-one - Risk and Safety

Hazard Class

IRRITANT, TOXIC

6-chloro-3-nitropyridin-2(1H)-one - Introduction

6-choro-3-nitropyridin-2 (1H)-one is a chemical compound with the formula C5H3ClN2O3. The following is a description of its nature, use, preparation and safety information:

Nature:
1. Appearance: 6-chloroo-3-nitropyridin-2 (1H)-one is a yellow crystal or crystalline powder.
2. Melting point: about 150-152°C.
3. Solubility: 6-chloro-3-nitropyridin-2(1H)-one is soluble in some organic solvents, such as ethanol and dimethyl sulfoxide, and slightly soluble in water.

Use:
1. chemical reagents: 6-choro-3-nitropyridin-2 (1H)-one is commonly used as a reagent for organic synthesis, such as for the synthesis of various organic compounds.
2. Synthesis of antibiotic intermediates: In the field of medicine, it can also be used to synthesize some antibiotics intermediates.

Method:
6-chloro-3-nitropyridin-2(1H)-one can be obtained by reacting p-nitropyridine with phosphorus chloride. The simple synthetic route is as follows:

1. Dissolve nitropyridine in carbon tetrachloride.
2. Add phosphorus chloride and stir and heat the reaction.
3. After completion of the reaction, the solution was filtered and the solvent was evaporated.
4. A yellow crystal of 6-chloroo-3-nitropyridin-2 (1H)-one was obtained.

Safety Information:
1.6-chloroo-3-nitropyridin-2 (1H)-one is an organic substance and should be handled in accordance with safe laboratory practices.
2. in use should avoid direct contact with skin and eyes, should wear appropriate personal protective equipment.
3. Avoid inhaling the gas of its powder or solution, and operate in a well-ventilated place.
4. Waste treatment shall comply with relevant regulations on chemical waste treatment.

Please note that the above introduction is for reference only. Professional personnel should be consulted for specific operation and use, and relevant safety data sheets and chemical instructions should be consulted.

Last Update：2024-04-09 15:18:00