6-fluoropyridin-2-amine
2-Amino-6-fluoropyridine
CAS: 1597-32-6
Molecular Formula: C5H5FN2
6-fluoropyridin-2-amine - Names and Identifiers
| Name | 2-Amino-6-fluoropyridine |
| Synonyms | EOS-60628 6-Fluoropyridin-2-amine 2-Amino-6-fluoropyridine 2-Fluoro-6-aminopyridine 2-AMINO-6-FLUOROPYRIDINE 6-FLUORO-PYRIDIN-2-YLAMINE 2-AMino-6-fluoropyriMidine 4''-ETHOXY-2,2,2-TRIFLUOROACETOPHENONE 1-(4-Ethoxyphenyl)-2,2,2-trifluoroethanone ethanone, 1-(4-ethoxyphenyl)-2,2,2-trifluoro- |
| CAS | 1597-32-6 |
| EINECS | 000-000-0 |
| InChI | InChI=1/C10H9F3O2/c1-2-15-8-5-3-7(4-6-8)9(14)10(11,12)13/h3-6H,2H2,1H3 |
6-fluoropyridin-2-amine - Physico-chemical Properties
| Molecular Formula | C5H5FN2 |
| Molar Mass | 112.11 |
| Density | 1.257±0.06 g/cm3(Predicted) |
| Melting Point | 59-61°C |
| Boling Point | 225.0±20.0 °C(Predicted) |
| Flash Point | 105°C |
| Vapor Presure | 0.0165mmHg at 25°C |
| Appearance | Solid |
| pKa | 2.26±0.24(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.452 |
| MDL | MFCD04114200 |
6-fluoropyridin-2-amine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
6-fluoropyridin-2-amine - Reference Information
| introduction | 2-amino-6-fluoropyridine is an organic intermediate, which can be prepared by nucleophilic substitution reaction between 2, 6-difluoropyridine and ammonia. There are reports that it can be used to prepare 2-fluoro-3, 6-dihydroxypyridine. 2-Fluoro-3, 6-dihydroxypyridine is a new type of fluorine-containing pyridine compound. Fluoropyridine compounds have the advantages of low dosage, low toxicity, high efficacy and strong metabolic ability, and are widely used in synthetic antibiotics, drugs for the treatment of cardiovascular diseases, agricultural pesticides, fungicides and herbicides. |
| preparation | 2, 6-difluoropyridine (50g,434mmol) ammonium hydroxide (200mL,28.0-30.0%) solution was heated in a steel sealed tube at 105 ℃ for 15 hours. The reactants were cooled in an ice bath, the precipitate was filtered, rinsed with cold water, and dried to obtain 2-amino-6-fluoropyridine (45.8g,94% yield) as a white solid. |
Last Update：2024-04-09 20:52:54
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