6-hydydroxy-7-methoxyquinazoline-4-one
6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
CAS: 179688-52-9
Molecular Formula: C9H8N2O3
6-hydydroxy-7-methoxyquinazoline-4-one - Names and Identifiers
6-hydydroxy-7-methoxyquinazoline-4-one - Physico-chemical Properties
| Molecular Formula | C9H8N2O3 |
| Molar Mass | 192.17 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Melting Point | 293 °C |
| Boling Point | 420.0±55.0 °C(Predicted) |
| Flash Point | 258.198°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 9.39±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.659 |
| MDL | MFCD07787563 |
6-hydydroxy-7-methoxyquinazoline-4-one - Reference Information
| Application | 6-hydroxy-7-methoxy-3H-quinazolin-4-one can be used as a pharmaceutical intermediate to synthesize other compounds with certain activity, such as It is a key intermediate for the synthesis of gefitinib (Gefitinib). Gefitinib is an orally available small molecule inhibitor for EGFR tyrosine kinase developed by AstraZeneca. Trade name Iressa. It was first marketed in Japan in 2002 and is mainly used for the treatment of locally advanced or metastatic non-small cell lung cancer. In 2005, it was approved by the State Food and Drug Administration (SFDA) for listing in China. |
| synthesis | method 1: the preparation method of 6-hydroxy-7-methoxy-3H-quinazoline -4-one includes the following steps: 1) preparation of 3-hydroxy-4-methoxybenzonitrile (II) dissolve the raw material isocyanin in formic acid, add formate and hydroxylamine hydrochloride, react at a suitable temperature. After the reaction is complete, after appropriate post-treatment, the product 3-hydroxy-4-methoxybenzonitrile (II) is obtained; 2) 5-hydroxy-4-methoxy-2-nitrobenzonitrile (III) Preparation of 3-hydroxy-4-methoxybenzonitrile (II) prepared in step 1) is dissolved in a solvent, then add the aqueous solution of potassium nitrate and fuming nitric acid, and react at a certain temperature. After the reaction is complete, after proper post-treatment, the product 5-hydroxy-4-methoxy-2-nitrobenzonitrile (III) is obtained. 3) Preparation of 6-hydroxy-7-methoxy-3H-quinazolin-4-one (IV) Dissolve the 5-hydroxy-4-methoxy-2-nitrobenzonitrile (III) prepared in step 2) in a solvent, then add a reducing agent, and react at a certain temperature. After the reaction is complete, add acid and cyclizing reagent, react at a certain temperature. After the reaction is complete, the product 6-hydroxy-7-methoxy-3H-quinazolin-4-one (IV) is obtained by appropriate post-treatment. |
Last Update：2024-04-09 21:54:55
Supplier List
Product Name: 6-Hydroxy-7-methoxyquinazolin-4(3H)-one Visit Supplier Webpage Request for quotation
CAS: 179688-52-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 179688-52-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 6-Hydroxy-7-methoxyquinazolin-4(3H)-one Request for quotation
CAS: 179688-52-9
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 179688-52-9
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
Product Name: 6-Hydroxy-7-methoxyquinazolin-4(3H)-one Visit Supplier Webpage Request for quotation
CAS: 179688-52-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 179688-52-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 6-Hydroxy-7-methoxyquinazolin-4(3H)-one Request for quotation
CAS: 179688-52-9
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 179688-52-9
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
View History