6-methoxyquinolin-8-amine

6-methoxyquinolin-8-amine - Names and Identifiers

Name	6-methoxy-8-quinolylamine
Synonyms	amichin wr15081 IFLAB-BB F1901-0147 6-methoxy-8-quinolinamin 6-methoxy-8-quinolylamine 6-methoxy-8-quinolinamine 6-methoxyquinolin-8-amine 8-amino-6-methoxyquinoline 6-Methoxy-8-aminoquinoline 6-methoxy-8-aminoquinoline 8-amino-6-methoxy-quinolin 6-Methoxy-8-amino-quinoline 6-Methoxy-8-amino quinoline 6-Methoxyquinolin-8-ylamine
CAS	90-52-8
EINECS	202-001-3
InChI	InChI=1/C10H10N2O/c1-13-8-5-7-3-2-4-12-10(7)9(11)6-8/h2-6H,11H2,1H3

6-methoxyquinolin-8-amine - Physico-chemical Properties

Molecular Formula	C10H10N2O
Molar Mass	174.2
Density	1.217±0.06 g/cm3(Predicted)
Melting Point	41 °C
Boling Point	137-138 °C(Press: 1 Torr)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Brown to Very Dark Brown Low Melting
pKa	3.49±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Stability	Incompatible with strong oxidizing agents.
Physical and Chemical Properties	White crystal. Melting point 41 ℃, boiling point 137-138 ℃(133Pa).

6-methoxyquinolin-8-amine - Risk and Safety

Hazard Class

IRRITANT

6-methoxyquinolin-8-amine - Nature

Open Data Verified Data

crystal. Melting Point 51 °c. Boiling Point (0.133kPa) 137~138 deg C.

Last Update：2024-01-02 23:10:35

6-methoxyquinolin-8-amine - Hair-making

Open Data Verified Data

6 methoxy 8 nitroquinoline in hydrochloric acid medium with iron powder reduced to 6-methoxy -8-amino quinine hydrochloride, and then neutralized with liquid alkali to get crude product, crude product after filtration, salting out, dehydrated to obtain finished product.

Last Update：2022-01-01 10:53:32

6-methoxyquinolin-8-amine - Use

Open Data Verified Data

pharmaceutical intermediates, mainly used for the preparation of antimalarial drugs primary ammonia quinoline phosphate, malaria quinoline.

Last Update：2022-01-01 10:53:32

6-methoxyquinolin-8-amine - Safety

Open Data Verified Data

toxic, detailed toxicity was not reported. Direct contact with the human body should be avoided during operation.
the container should be packed in plastic bags lined with iron or wood barrels and stored in a cool and ventilated place. Protection against heat, sun and moisture. Regulation of storage and transport of chemicals.

Last Update：2022-01-01 10:53:33

6-methoxyquinolin-8-amine - Reference Information

Use

intermediates of antimalarial drugs primaquine phosphate, pentaquine, and vivaquine.

production method

6-methoxy-8-nitroquinoline is obtained by reduction with iron powder in hydrochloric acid medium and neutralization with liquid alkali. Hydrochloric acid was put into a glass-lined reaction pan, and the temperature was raised to 50 ° C., and 6-methoxy-8-nitroquinoline and iron powder were added. The whole was added at 65-70 ° C. In 3.5H, incubated for 2H, cooled and filtered to give crude 8-amino-6-methoxyquinoline hydrochloride. After salting-out purification, 8-amino -6-methoxyquinoline was precipitated by neutralization to pH 7 with dilute alkali, and the crude product was obtained by filtration and purified with toluene to obtain 8-amino-6-methoxyquinoline. The yield was 65%. Product specifications: content ≥ 65%. Raw material consumption quota: 6-methoxy-8-nitroquinoline (94%)1765kg/t, hydrochloric acid (37%)10479kg/t, iron filings (industrial) 2519kg/t.

Last Update：2024-04-09 02:00:12