6-氟-3-羟基吡嗪-2-腈

6-氟-3-羟基吡嗪-2-腈 - Names and Identifiers

Name	2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-
Synonyms	Favipiravir Impurity 13 FAVIPIRAVIR intermediate N-1 5-fluoro-2-oxo-1H-pyrazine-3-carbonitrile 6-fluoro-3-hydroxypyrazine-2-carbonitrile Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo- 6-fluoro-3-oxo-3,4-dihydropyrazine-2-carbonitrile 6-Fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-
CAS	356783-31-8

6-氟-3-羟基吡嗪-2-腈 - Physico-chemical Properties

Molecular Formula	C5H2FN3O
Molar Mass	139.0873
Density	1.53±0.1 g/cm3(Predicted)
Melting Point	126 - 129oC
Solubility	Acetonitrile (Slightly), DMSO (Slightly)
Appearance	Solid
Color	Pale Yellow to Light Yellow
pKa	7.74±0.60(Predicted)
Storage Condition	-20°C Freezer, Under inert atmosphere

6-氟-3-羟基吡嗪-2-腈 - Upstream Downstream Industry

Raw Materials

1374986-03-4
3,6-dichloropyrazine-2-carbonitrile
3-HYDROXYPYRAZINE-2-CARBOXAMIDE
5-Fluoro-isoxazolo[4,5-b]pyrazine-3-carboxylic acid methyl ester
3,6-difluoropyrazine-2-carbonitrile
METHYL 5-HYDROXYISOXAZOLO[4,5-B]PYRAZINE-3-CARBOXYLATE
METHYL 5-CHLOROISOXAZOLO[4,5-B]PYRAZINE-3-CARBOXYLATE

6-氟-3-羟基吡嗪-2-腈 - Introduction

2-pyrazinecarbonitril, 6-fluoro-3,4-dihydro-3-oxo-is an organic compound with the chemical formula C6H3FN2O. It is a white crystalline solid, soluble in organic solvents such as methanol and ethanol.

Regarding its properties, 2-pyrazinecarbonitril, 6-fluoro-3,4-dihydro-3-oxo-is a combustible substance, which can decompose at high temperatures to produce toxic gases. In addition, it is irritating to the skin and eyes, and should be rinsed with water immediately after contact.

In terms of application, 2-Pyrazinecarbonitrile, 6-fluoro-3, 4-dihydro-3-oxo-are commonly used as intermediates in organic synthesis. It can be used to synthesize various organic compounds containing pyrazine ring, such as drugs, dyes and pesticides.

Regarding the preparation method, 2-Pyrazinecarbonitrile, 6-fluoro-3, 4-dihydro-3-oxo-can be obtained by the reaction of pyrazine and hexafluoroacetic acid. In the specific process, hexafluoroacetic acid is first added to the reaction solvent, then pyrazine is added and the reaction is heated, and finally the product can be purified by crystallization.

Pay attention to safety during use, avoid contact with skin and eyes, and avoid inhaling dust or gas. Wear chemical protective gloves, protective glasses and masks during operation to ensure that the operation area is well ventilated. When disposing of waste, comply with local regulations and dispose of it correctly.

Last Update：2024-04-10 22:30:23