6-甲基-3-硝基-5-溴吡啶-2(1H)-酮
5-BROMO-3-NITRO-6-METHYLPYRIDIN-2(1H)-ONE
CAS:
Molecular Formula: C6H5BrN2O3
6-甲基-3-硝基-5-溴吡啶-2(1H)-酮 - Names and Identifiers
6-甲基-3-硝基-5-溴吡啶-2(1H)-酮 - Physico-chemical Properties
| Molecular Formula | C6H5BrN2O3 |
| Molar Mass | 233.0195 |
| Storage Condition | Room Temprature |
6-甲基-3-硝基-5-溴吡啶-2(1H)-酮 - Introduction
(1H)-ONE, also known as 5-bromo-3-nitro-6-methylpyridine-2 (1H)-ONE, belongs to the pyridine group of compounds. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White solid
-Molecular formula: C6H5BrN2O3
-Molecular weight: 227.02g/mol
-Melting Point: 96-97 ° C
-Boiling point: 358.2 ° C
-Solubility: Soluble in organic solvents such as ethanol, ether and chloroform, insoluble in water.
Use:
-(1H)-ONE can be used as an intermediate in organic synthesis and can be used to synthesize other compounds.
-It also has certain applications in the field of medicine, such as the preparation of drugs or drug candidate compounds.
Method:
-The preparation method of (1H)-ONE can be carried out by the following steps:
1. 2-amino-5-bromopyridine is subjected to amide reaction with methyl ethanone to obtain 5-bromo-2-methylpicolinamide.
2. In the presence of sulfuric acid, 5-bromo -2-methyl pyridine amide and concentrated nitric acid were reacted to obtain pyridine (1H)-ONE.
3. The product is purified by crystallization to obtain the target compound.
Safety Information:
-(1H)-ONE is an organic compound, and its potential danger should be paid attention. For example, it may have an irritating effect on the eyes, skin and respiratory system.
-Wear appropriate protective equipment when handling the compound, including chemical goggles, gloves, and lab coats.
-When using the compound, it should be done in a well-ventilated place, and avoid direct contact with the skin and inhalation of its vapor.
-In case of accidental contact, rinse immediately with plenty of water and seek medical advice.
Nature:
-Appearance: White solid
-Molecular formula: C6H5BrN2O3
-Molecular weight: 227.02g/mol
-Melting Point: 96-97 ° C
-Boiling point: 358.2 ° C
-Solubility: Soluble in organic solvents such as ethanol, ether and chloroform, insoluble in water.
Use:
-(1H)-ONE can be used as an intermediate in organic synthesis and can be used to synthesize other compounds.
-It also has certain applications in the field of medicine, such as the preparation of drugs or drug candidate compounds.
Method:
-The preparation method of (1H)-ONE can be carried out by the following steps:
1. 2-amino-5-bromopyridine is subjected to amide reaction with methyl ethanone to obtain 5-bromo-2-methylpicolinamide.
2. In the presence of sulfuric acid, 5-bromo -2-methyl pyridine amide and concentrated nitric acid were reacted to obtain pyridine (1H)-ONE.
3. The product is purified by crystallization to obtain the target compound.
Safety Information:
-(1H)-ONE is an organic compound, and its potential danger should be paid attention. For example, it may have an irritating effect on the eyes, skin and respiratory system.
-Wear appropriate protective equipment when handling the compound, including chemical goggles, gloves, and lab coats.
-When using the compound, it should be done in a well-ventilated place, and avoid direct contact with the skin and inhalation of its vapor.
-In case of accidental contact, rinse immediately with plenty of water and seek medical advice.
Last Update：2024-04-09 02:00:50
