60008-03-9

Name	GLABRENE
Synonyms	GLABRENE 2',2'-Dimethyl-3,6'-bi[2H-1-benzopyran]-5',7-diol 2',2'-Dimethyl-[3,8'-bi-2H-1-benzopyran]-5',7-diol [3,8'-Bi-2H-1-benzopyran]-5',7-diol, 2',2'-dimethyl- 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol
CAS	60008-03-9

Molecular Formula	C20H18O4
Molar Mass	322.35
Density	1.293±0.06 g/cm3(Predicted)
Melting Point	200-203°C
Boling Point	536.3±50.0 °C(Predicted)
Solubility	Insoluble in water, soluble in methanol, ethanol and ether.
Appearance	Pale yellow powder
pKa	9.50±0.20(Predicted)
Storage Condition	2-8℃
MDL	MFCD28100642

Overview	light licorice, also known as light fruit licorice, is the main active ingredient of legume light licorice root. It is light yellow powder, insoluble in water, soluble in methanol, ethanol and ether. Modern research shows that the light of the licorice has a variety of pharmacological activities, such as scavenging superoxide ion, inhibiting tyrosinase and estrogen-like effects. However, there is no literature reported that the anti-cancer effect of light licorice has more prominent.
effect	the inhibitory effect of glabridin on the proliferation of HepaRG and Caco2 cells may be related to the induction of apoptosis and G2/M arrest.
biological activity	Glabrene is an isoflavone derived from the root of Glycyrrhiza uralensis, which has estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 value of 3.5 μm.
Target	IC50: 3.5 μm (Tyrosinase)

Last Update：2024-04-09 21:01:54

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60008-03-9

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