61-19-8
Adenosine 5'-monophosphate
CAS: 61-19-8
Molecular Formula: C10H14N5O7P
61-19-8 - Names and Identifiers
| Name | Adenosine 5'-monophosphate |
| Synonyms | AMP a5mp 5-AMP adenyl adenovite cardiomone Adenylic acid 5-Adenylic acid amp[nucleotide] amp(nucleotide) adenosine phosphate OLS) 18, 20-HEMIKETAL adenosine5'-phosphate adenosine5'-phosphate Adenosine-5-monophoshpate Adenosine 5-monophosphate 5'-O-phosphonatoadenosine Adenosine 5'-monophosphate Adenosine-5-monophosphoric acid 5'-Adenosine Monophosphoric Acid Adenosine 5' Monophosphoric Acid Adenosine-5'-monophosphate,Free acid Adenosine 5'-monophosphate,free acid adenosine,mono(dihydrogenphosphate)(ester) 5'-Adenosine monophosphonic acid(free acid) )-monophosphate disodium salt (mixed isomers) 9-(5-O-phosphono-alpha-D-lyxofuranosyl)-9H-purin-6-amine |
| CAS | 61-19-8 |
| EINECS | 200-500-0 |
| InChI | InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 |
61-19-8 - Physico-chemical Properties
| Molecular Formula | C10H14N5O7P |
| Molar Mass | 347.22 |
| Density | 2.32±0.1 g/cm3(Predicted) |
| Melting Point | 178-185 °C |
| Boling Point | 798.5±70.0 °C(Predicted) |
| Specific Rotation(α) | -47.5°(20°C，2%于2%氢氧化钠中)。 |
| Flash Point | 436.728°C |
| Water Solubility | Soluble in water. |
| Solubility | Soluble in alkaline water |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | Colorless to white |
| Merck | 14,158 |
| pKa | 3.8, 6.2(at 25℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00065023 |
| Physical and Chemical Properties | White crystals. mp196-200 C (decomposition). Specific rotation -47.5 °(20 °c, 2% in 2% sodium hydroxide). Soluble in water, slightly soluble in alcohol, insoluble in ether. |
| Use | Can be used as the production of nucleic acid drug intermediates, health food and biochemical reagents, and used in the manufacture of adenosine triphosphate, cyclic adenosine monophosphate and other biochemical drugs |
61-19-8 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | AU7480500 |
| TSCA | Yes |
| HS Code | 29389090 |
| Toxicity | LD50 intraperitoneal in mouse: 4gm/kg |
61-19-8 - Reference
| Reference Show more | 1. Zhu Yahui, Cao, Wen, Hongzhang, Chaohua. Evaluation of flavor characteristics of dried scallop Chlamys farreri [J]. Food and Fermentation Industry, 2016, 42(012):183-188. 2. Zhu Yahui, Cao Wenhong, Liu Zhongjia, etc. Effect of heat treatment on the formation of characteristic flavor of Chlamys farreri [J]. Food Science, 2017, 29 (20):131-138. 3. Zhang Xiaokang Shangguan Super Chen Changbao Zhang Lili Zhou Jie Zhu Shuhua. Regulation of nitric oxide on energy metabolism of refrigerated peach fruit [J]. Preservation and processing 2019 19(04):1-9. 4. Huang Shengdong Chen Song Pan Jiang ball Cai Ying Li Si Dong Li puwang Yang Xihong Wu Yuying. Effects of different molecular weight chitosan on preservation of tilapia fillets during cold storage [J]. Science and Technology of Food Industry, 2015, 36(19):318-321. 5. Wei Yunyun, Gong Xue, Xin Guang, et al. Study on the effect of drying methods on the flavor of Boletus Corynebacterium from point-handle based on chemical analysis and electronic tongue [J]. Journal of Food Science, 2018(18). 6. Wu Zhanxia, Pan Jiang ball, Yang Zi-Ming, Chen Song, Huang Shengdong, Li puwang, Yang Xihong, Li Si-dong. Effect of mixed molecular weight chitosan combined with ozone sterilization on preservation of tilapia fillets during cold storage [J]. Journal of Guangdong Ocean University, 2016,36(03):71-75. 7. Chen Shi-da, Guo Mei-Chen, Yang Liu-ming, et al. Effect of pretreatment on fresh-keeping quality of cultured pseudosciaena crocea [J]. Science and Technology of food industry, 2018(17):258-262. 8. Yin Chaomin, fan Xiuzhi, Shi Defang, et al. HS-SPME-GC-MS analysis of flavor components in five fresh edible fungi by HPLC [J]. Science and Technology of Food Industry 2019 040(003):254-260. 9. Liu Xinye, Li Yunshu, Ma Qi, Wu Zijian, Xu Huaide, Li Mei. Effects of different drying methods on taste components of pleurotus eryngii [J]. Food Research and Development, 2020,41(16):8-13. 10. Tang Jianxin, Qin Suyi, Ren Hao, Yu guanchu, Xin Guang, Sun Binxin. Effect of initial oxygen concentration on quality of postharvest Agaricus bisporus [J]. Packaging Engineering, 2021,42(01):8-17. 11. Zhao Simin, bevenge, Bao Zeyang, Guan Feng, Yuan Yongjun. Study on the effect of fluidized ice on the preservation of large yellow croaker [J]. Science and Technology of food industry, 2021,42(01):297-303. 12. Jiang Yu, Zhang Miao, Tang Jing, Jin Peng, Zheng Yong Hua. Effects of cold shock combined with salicylic acid treatment on chilling injury and energy and proline metabolism of cucumber fruit [J]. Journal of Nuclear Agriculture, 2021,35(01):128-137. 13. Zhiyong Zhang, Xiaoyu Zhang, Huang Xin, Xue Gong, Yudi Wang, Lu Wang, Xingxin Sun,Umami taste and its association, food Chemistry,Volume 279,2019,Pages 179-186,ISSN 0308- 14. Liu, L, Fang, J, Liang, X-F, He, S. Nucleotide promotes feed intake and protein utilization via regulating the gene expression of feeding and nitrogen metabolism in juvenile Chinese perch (Siniperca chuatsi). Aquacult Nutr. 2020; 26: 1702- 1712. https://do 15. [IF=7.514] Saili Zhang et al."Effects of negative air ions treatment on the quality of fresh shiitake mushroom (Lentinus edodes) during storage."Food Chem. 2022 Mar;371:131200 16. [IF=7.514] Yao Feng et al."Comparison of the umami taste and aroma of dried Suillus granulatus packed using four different packaging methods."Food Chem. 2022 Jan;366:130570 17. [IF=6.475] Donglu Fang et al."Microflora and umami alterations of different packaging material preserved mushroom (Flammulina filiformis) during cold storage."Food Res Int. 2021 Sep;147:110481 18. [IF=5.548] Qian Luo et al."Portable functional hydrogels based on silver metallization for visual monitoring of fish freshness."Food Control. 2021 May;123:107824 19. [IF=5.537] Bingxin Sun et al."Effect of 1-methylcyclopropene (1-MCP) on quality of button mushrooms (Agaricus bisporus) packaged in different packaging materials."Postharvest Biol Tec. 2020 Jan;159:111023 20. [IF=5.328] Li Xin Ping et al."The signaling role of extracellular ATP in co-culture of Shiraia sp. S9 and Pseudomonas fulva SB1 for enhancing hypocrellin A production."Microb Cell Fact. 2021 Dec;20(1):1-15 21. [IF=5.268] Huanqing Niu et al."Immobilization of a polyphosphate kinase 2 by coordinative self-assembly of his-tagged units with metal-organic frameworks and its application in ATP regeneration from AMP."Colloid Surface B. 2019 Sep;181:261 22. [IF=4.24] Na Xu et al."Exploration of flavor and taste of soft-boiled chicken at different post-mortem aging time: Based on GC-IMS and multivariate statistical analysis."Food Biosci. 2021 Oct;43:101326 23. [IF=3.463] Xuemei Zhao et al."Postharvest short-time partial dehydration affects shiitake mushroom (Lentinus edodes) storage quality and umami taste."Sci Hortic-Amsterdam. 2021 Sep;287:110274 |
61-19-8 - Reference Information
| FEMA | 4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| usage limit | GB 2760-2001: infant formula milk powder 0.20~0.58g/kg (based on total nucleotides). |
| Use | clinical use for disseminated sclerosis, porphyria, pruritus, liver disease, Varicose ulcer complications. The compound eye drops mainly composed of adenosine can be used for eye fatigue, central retinitis, corneal pannus and herpes and other corneal surface diseases. Local erythema, systemic vasodilation, flushing, dizziness, Dyspnea, palpitations were noted in intramuscular injection. Nutrition Fortifier. it can be used as an intermediate for the production of nucleotide drugs, food additives and biological products it can be used as an intermediate for the production of nucleic acid drugs, health food and biochemical reagents, and for the manufacture of adenosine triphosphate (ATP), cyclic adenosine monophosphate (cAMP) and other biochemical drugs. it can be used to produce nucleic acid drug intermediates, health food and biochemical reagents, and used to manufacture adenosine triphosphate, cyclic adenosine monophosphate and other biochemical drugs This product is a nucleotide product, can be used as the production of nucleotide drug intermediates, food additives and biochemical products, for the production of antiviral drugs, synthetic energy drugs and cardiovascular and cerebrovascular drugs, such as vidarabine, ATP, 3 '-5'-cyclic adenosine monophosphate, etc. A naturally occurring nucleotide that facilitates binding of APS reductase inhibitors and activates adenosine receptor agonists. |
| production method | nucleic acid was extracted from the bacteria of Candida utilis with hot water, after the hydrolysis of the enzyme after separation. with mycelium as raw material extraction, precipitation mycelium plus 3 times the amount of water, processing industry alkali, so that the concentration of 0.25%(g/100 ml), after stirring for 1H, 20% sulfuric acid was added to adjust pH = 7, and the filtrate was filtered. The filtrate was adjusted to pH = 20% with 2.5 sulfuric acid, and centrifuged to obtain nucleic acid sludge. Mycelium [sodium hydroxide] →[1H] extract [20% sulfuric acid] →[pH7, filtration] filtrate [20% sulfuric acid] →[pH2.5, centrifugation] Nucleic Acid mud dissolution, enzymatic hydrolysis, adsorption, elution the nucleic acid mud is prepared into 1% solution, adjusted to pH = 6-6.2 with 10% ammonia water, heated at 90 °c for 20min, cooled, centrifuged, after warming the supernatant to 65-70 ℃, add 1/3 phosphodiesterase solution, raise the temperature to 90 ℃ after 2H, cool to room temperature after 10min, add 20% sulfuric acid solution to adjust pH = 2.5-3, filter, the filtrate was adjusted to pH = 10% -7.2 with 7.5 ammonia water, and 0.3%(3G/L) diatomite was added to aid filtration. The filtrate was put on a 717 type anion exchange resin column, elution was performed with 0.05mol/L sulfuric acid. Nucleic acid mud [ammonia] →[pH6-6.2, 90 ℃, 20min] clear solution [phosphodiesterase] →[65-70 ℃, 2H] hydrolysate [717 resin] → adsorbate [sulfuric acid] → eluent [732 resin] → AMP, CMP, GMP mixed adsorption, elution, the crystallization eluate was adsorbed on a 732 type cation exchange number lipid column and eluted with distilled water at pH. When the eluate was red with bromine water, the eluate was collected and concentrated to 80-90mg/ml under reduced pressure, diatomite was added, stirred for 30min, filtered, the filtrate was adjusted to pH = 2.5 with 6mol/L hydrochloric acid, stirred and cooled to fully crystallize, filtered, washed with anhydrous ethanol for 3 times, and dried at 60 ℃ in vacuum, finished AMP product |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intraperitoneal-mouse LD50: 4000 mg/kg |
| flammability hazard characteristics | flammability; Toxic nitrogen oxide and phosphorus oxide fumes generated by heat |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, carbon dioxide |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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