| Name | Sisthsne |
| Synonyms | Sisthsne Phenapronil |
| CAS | 61069-78-1 |
| Molecular Formula | C16H19N3 |
| Physical and Chemical Properties | Chemical properties viscous and dark brown liquid. The boiling point is 200 ℃(93Pa) and the vapor pressure (25 ℃) is 0.133Pa. Solubility: 1% in water, 25% in ethylene glycol, 50% in both diketone and xylene. Stable in acidic or alkaline media. The melting point of its hydrochloride is 160-162°C. |
| Use | Use: methanesulfonate is a new broad-spectrum systemic fungicide, which is an inhibitor of ergosterol biosynthesis. It has good biological activity against ascomycetes, Basidiomycetes, and many other fungi. Some important cereals and horticultural crops of a variety of fungal diseases with systemic fungicidal activity, on wheat leaf rust, rust Rod disease, broad bean gray mold, peanut brown spot disease, the control effect of Fusarium wilt and Cotton leaf blight was good. It can also be used as a seed dressing agent. |
using phenylacetonitrile, chlorobutane and imidazole as raw materials, it is obtained by the following process. 1. Preparation of α-n-Butylphenylacetonitrile 119.2g of phenylacetonitrile, 185.2g of chlorobutane and 1.61g of tetrabutylammonium bromide with 98% content are slowly added into the dissolution of 160g of 50% sodium hydroxide under constant stirring. The reaction solution gradually changed from light yellow to brown red. Due to the exotherm of the reaction, the temperature rose from 25 ℃ to 88 ℃ within 1h, and began to reflux, and then slowly cooled to 65 ℃ to continue the reaction for 4-5h. Add 300ml of water, let it stand and delaminate, separate out the organic layer, distill under reduced pressure, and collect the fraction at 70 ℃(0.266kPa), which is α-n-butylbenzene acetonitrile. Preparation of 2.1-Chloro-2-cyano-2-ylethane 91g α-n-butylbenzene acetonitrile (content 98%), 85g dichloromethane and 6.5g tetrabutylammonium bromide were uniformly stirred under the protection of nitrogen, and 160g 50% sodium hydroxide solution was slowly added. The reaction is exothermic, the temperature is raised to 65%, the reflux is 4-5h, 300ml of water is added after cooling, the organic layer is separated, and the 1-chloro-2-cyano-2-phenylethane is distilled under reduced pressure. 3. Preparation of miidonitrile 87.6g of 50% sodium hydroxide solution, 132g of imidazole and 200g of dimethyl sulfoxide are stirred and heated. When the temperature rises to 85 ℃, the former fraction is steamed out under reduced pressure. When the material temperature reaches 120 ℃, some water and low boiling matter are steamed out. When the temperature continues to rise to 135 ℃, 109g of 1-chloro-2-cyanide-2-phenylethane is gradually added. At 135 ℃, the temperature is kept for 8h, the former fraction is steamed out under reduced pressure, 150ml of water is added, nitrogen is added for protection, 100g of xylene is added, and the layer is left standing. The organic layer is separated, decompressed and dissolved into brown liquid, and then treated to obtain a white solid with a content of 95-99%. Processed into 25% emulsifiable concentrate for use.