612069-27-9

612069-27-9 - Names and Identifiers

Name	3'-N,N-Di(desmethyl) Azithromycin
Synonyms	Azithromycin EP mpurity E 3′-(N,N-Didemethyl)azithromycin N',N'-Di(desmethyl) Azithromycin 3'-N,N-Di(desMethyl) AzithroMycin 3'-N,N-Di(desmethyl) Azithromycin 3a€-N,N-Di(desmethyl) Azithromycin (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(3-AMino-3,4,6-trideoxy-β-D-xylo-hexopyranosyl)oxy]-13-[(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-1-oxa-
CAS	612069-27-9

612069-27-9 - Physico-chemical Properties

Molecular Formula	C36H68N2O12
Molar Mass	720.93
Density	1.20±0.1 g/cm3(Predicted)
Melting Point	>209°C (dec.)
Boling Point	817.3±65.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	13.28±0.70(Predicted)
Storage Condition	-20°C Freezer, Under inert atmosphere

612069-27-9 - Introduction

3 '-N,N-Di(desmethyl) Azithromycin is a di-demethylated Azithromycin derivative. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 3 '-N,N-Di(desmethyl) Azithromycin is white or off-white crystalline powder.
-Solubility: Insoluble in water, but soluble in organic solvents such as chloroform, ether and ethyl acetate.
-chemical structure: its chemical structure has a 1,3-benzodiazepine ring and a 16-member ring with 14-position hydroxyl group, which is an antibiotic molecule.

Use:
3 '-N,N-Di(desmethyl) Azithromycin is mainly used as a broad-spectrum antibiotic, which can be used to treat infections caused by gram-positive and negative bacteria, such as respiratory tract infections, skin infections and urinary tract infections.

Preparation Method:
3 '-N,N-Di(desmethyl) Azithromycin can be prepared by the following steps:
1. Azithromycin reacts with propyl nitrite in dichloromethane to generate 3 '-N,N-Di(desmethyl) Azithromycin.
2. The product was purified by crystallization using an acetic acid-water mixed solution.
3. The pure product is obtained by drying and other subsequent steps.

Safety Information:
- 3 '-N,N-Di(desmethyl) Azithromycin should strictly abide by the relevant safety operation procedures during use.
-It may cause allergic reactions to certain people, so you need to pay attention to allergy testing before use.
-in the process of use, should be in accordance with the doctor's advice and drug instructions in the dose of use, to avoid excessive use.
-If necessary, consult a professional doctor to obtain more detailed safety information.

Last Update：2024-04-09 19:05:58