61445-55-4
N-Nitroso-N-methyl-4-aminobutyric Acid
CAS: 61445-55-4
Molecular Formula: C5H10N2O3
61445-55-4 - Names and Identifiers
61445-55-4 - Physico-chemical Properties
| Molecular Formula | C5H10N2O3 |
| Molar Mass | 146.15 |
| Density | 1.3394 (rough estimate) |
| Melting Point | >25 °C |
| Boling Point | 265.74°C (rough estimate) |
| Solubility | Chloroform (Soluble), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Meth |
| Appearance | Morphological Solid |
| Color | Off-White to Yellow Oil to |
| pKa | 4.57±0.10(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.4954 (estimate) |
61445-55-4 - Uses and synthesis methods
Introduction
Losartan genotoxic impurity (NMBA) is a known carcinogenic chemical substance in animals and potential humans. It is followed by N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) The third genotoxic impurity detected in ARBs drugs. In the FDA's published list of nitrosamines for ARBs, the maximum daily allowable intake of NMBA is 0.96ppm.
Preparation
5.0g(0.05mol)N-methylpyrrolidone is added into a 250mL four-mouth flask, 50g toluene is added, stirring is dissolved, 0.5g tetrabutyl ammonium bromide is added, and sodium hydroxide aqueous solution (sodium hydroxide: 4g(0.1mol) is added; Water: 40g), heating to 50 ℃, stirring for 28h, stirring for reaction, separating, organic discarding, adjusting pH = 1.0 with hydrochloric acid, filtering, filtrate collection, the filter cake is discarded.
Last Update：2024-04-10 22:29:15
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Product Name: Losartan Impurity 17 Visit Supplier Webpage Request for quotationCAS: 61445-55-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: N-Nitroso-N-methyl-4-aminobutyric Acid Visit Supplier Webpage Request for quotation
CAS: 61445-55-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 61445-55-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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