614730-97-1

614730-97-1 - Names and Identifiers

Name	tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
Synonyms	153708 1-Boc-4-fluoro-4-(hydroxy... 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE 1-BOC-4-fluoro-4-(hydroxymethyl)-piperidine tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester 1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER 1-piperidinecarboxylic acid, 4-fluoro-4-(hydroxymethyl)-, 1,1-dimethylethyl ester
CAS	614730-97-1
InChI	InChI=1/C11H20FNO3/c1-10(2,3)16-9(15)13-6-4-11(12,8-14)5-7-13/h14H,4-8H2,1-3H3

614730-97-1 - Physico-chemical Properties

Molecular Formula	C11H20FNO3
Molar Mass	233.28
Density	1.13±0.1 g/cm3(Predicted)
Boling Point	311.0±27.0 °C(Predicted)
Flash Point	141.898°C
Vapor Presure	0mmHg at 25°C
pKa	14.94±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.481

614730-97-1 - Introduction

tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is an organic compound with the chemical formula C12H21NO3F and a molecular weight of 239.30g/mol. It is a solid powder, soluble in some organic solvents such as methanol and dimethyl ketone.

tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is an important intermediate compound, which has a wide range of applications in the field of pharmaceutical synthesis and organic synthesis. It can be used as an important intermediate in the synthesis of drugs, involved in the synthesis of a variety of drugs, such as anti-cancer drugs and antipsychotic drugs. In addition, it can also be used as a chiral inducer to catalyze reactions in organic synthesis to improve yield and selectivity.

The method of preparing tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is usually completed by a series of organic synthesis steps. A common synthetic method is the condensation reaction of 1-hydroxy-4-tert-butylpiperidine with hydrofluoric acid ester, followed by further treatment with dimethyl carbonate to obtain the target compound.

in the use of tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate need to pay attention to its safety. It is an irritating compound that may cause irritation to the eyes, skin and respiratory tract. Appropriate protective equipment such as goggles, gloves and protective masks should be worn during operation. In addition, the compound should be stored and handled properly, avoiding contact with oxidants and strong acids and bases to avoid triggering dangerous reactions. In the use of the process should follow the relevant safety procedures and instructions.

Last Update：2024-04-09 20:52:54