61791-12-6
polyoxyethylene (20) castor oil (ether, ester)
CAS: 61791-12-6
Molecular Formula:
61791-12-6 - Names and Identifiers
| Name | polyoxyethylene (20) castor oil (ether, ester) |
| Synonyms | RO 40 RO series BY series cremophor el Emulsifier EL Cremophor EL series Emulsifier EL series emulsifier series |
| CAS | 61791-12-6 |
| EINECS | 500-147-5 |
61791-12-6 - Physico-chemical Properties
| Density | 1.05g/mLat 20°C |
| Boling Point | 232.6℃[at 101 325 Pa] |
| Flash Point | 257℃ |
| Water Solubility | 24.11mg/L at 25℃ |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Viscous Liquid |
| Color | Clear yellow |
| pKa | 0[at 20 ℃] |
| PH | 5.0-7.0 (1g/10 mL in H2O) |
| Storage Condition | REFRIGERATOR (+4C) |
| Stability | Stable. Incompatible with storng oxidizing agents. |
| MDL | MFCD00130879 |
| Physical and Chemical Properties | This series of products are light yellow paste, resistant to hard water, acid, alkali and inorganic salts. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
61791-12-6 - Risk and Safety
| WGK Germany | 1 |
| RTECS | GO5661000 |
| HS Code | 15153090 |
61791-12-6 - Reference
| Reference Show more | 1. Zhao, Jing, Jian, Qiang, Zhang, Beibei, et al. Pharmacokinetics of CB1R partial antagonist alisol G in rats and preliminary evaluation of blood-brain barrier permeability [J]. Journal of Chinese pharmaceutical industry, 2020v.51(01):106-112 151. 2. Ma Shuwei, Wang Yongjie, Chen Min et al. Optimization of preparation technology of compound Glycyrrhiza microemulsion by D-optimal mixture design [J]. Chinese Journal of Traditional Chinese Medicine, 2018 043(006):1131-1138. 3. Chen Xunlong, Liang Xinli, Ding Haobo, etc. Preparation and In Vitro Quality Evaluation of curcumin supersaturated self-Nanoemulsion [J]. Chinese Journal of Traditional Chinese Medicine, 2020, 26 (15). 4. Zhong Linying, Tian Wan Wan, Liu Caifeng, etc. Preparation of tetramethylpyrazine microemulsion and comparative study on in vitro release of different particle size microemulsions [J]. Chinese herbal medicine, 50 Vol. 21, 2019, pages 5331-5238, ISTIC PKU CSCD CA. 5. Cheng Zhihong, Song Dingzhong, Yuan Jie, et al. In vivo intestinal absorption of effective parts of Alisol in rats [J]. Chinese Journal of Pharmaceutical Industry, 2015, 29 (09):985-990. 6. Wan Fang. Study on controlled release drug delivery system of Ginkgo biloba extract by self-microemulsifying osmotic pump [J]. Chinese Journal of Clinical Pharmacology, 2020, v.36;No.311(09): 103-106. 7. Liu Yongfei. Preparation and dissolution rate of resveratrol supersaturated self-microemulsion [J]. Science and Technology Wind, 2019(36):135-137. 8. Zhou Yimei, Jin Ying, Wu Lei, et al. Effect of chlorogenic acid on paclitaxel-induced peripheral neuropathic pain in mice [J]. Journal of Hubei University of Science and Technology (Medical Sciences), 2019, 033(003):P.188-191. 9. Liu Fuhe, ni Wenjuan, Yu Songlin, Huang anhao, Zou Jiafeng, Li fanzhu. Preparation of hydroxysafflor yellow A phospholipid complex self-microemulsifying drug delivery system and its pharmacokinetics in rats [J]. China Modern Applied Pharmacy, 2021,38(01):14-19. 10. Kang, Qian, et al. "Application of quality by design approach to formulate and optimize." Journal of Drug Delivery Science and Technology 52 (2019): 1032-1041.https:// doi.org/10.10 11. Wu, JY., cai, JX., Li, YJ. et al. 3,5,4′-Trimethoxy-trans-stilbene loaded microemulsion for cutaneous melanoma therapy by transdermal drug delivery. Drug Deliv. and Transl. Res. 11, 169-181 (2021). https://doi.org/10.1007/s13346-020-00757-w 12. [IF=3.205] Zhihong Cheng et al."Simultaneous determination of three triterpenes in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Rhizoma Alismatis extract."J Chromatogr B. 2016 Jan;1008:32 13. [IF=6.165] Qing Li et al."Revealing the effects of multi-scale molecules on α-linolenic acid-loaded W1/O/W2 microemulsion: A combined study from physical properties antioxidant capacity and in vitro release kinetics."J Mol Liq. 2020 Apr;303:112675 14. [IF=6.165] Xue Wang et al."Evaluation of the oxidation stability and anti-cancer cell activity of Paeonia ostii seed oil and its linolenic acid fractions delivered as microemulsions."J Mol Liq. 2021 Nov;342:117579 15. [IF=6.165] Aibibai Amuti et al."Formulation and characterization of curcumin-loaded microemulsions: Evaluation of antioxidant stability and in vitro release."J Mol Liq. 2021 Aug;336:116881 16. [IF=5.81] Guo Cui et al."Network Pharmacology and Molecular Docking on the Molecular Mechanism of Luo-hua-zi-zhu (LHZZ) Granule in the Prevention and Treatment of Bowel Precancerous Lesions."Front Pharmacol. 2021 Feb;12:144 17. [IF=5.645] Xueping Wang et al."Developing peony (Paeonia suffruticosa Andr.) seed oil products based on α-Linolenic acid by microemulsification."Ind Crop Prod. 2021 Mar;161:113211 18. [IF=5.279] Qing Li et al."Antiproliferative Ability and Fluorescence Tracking of α-Linolenic Acid-Loaded Microemulsion as Label-Free Delivery Carriers in MDA-MB-231 Cells."J Agr Food Chem. 2019;67(41):11518-11526 |
61791-12-6 - Standard
Authoritative Data Verified Data
This product is polyoxyethylene glycerol triricinoleate, which also contains a small amount of polyethylene glycol ricinoleate, free ethylene glycol. This product was obtained by reacting 1 mol of glycerol ricinoleate with 35MOL of ethylene oxide.
Last Update：2024-01-02 23:10:35
61791-12-6 - Trait
Authoritative Data Verified Data
- This product is white, off-white or light yellow paste or viscous liquid; Micro special odor.
- This product is highly soluble in ethanol.
relative density
The relative density of this product (General 0601) is 1.05~1.06.
viscosity
The kinematic viscosity of this product (General rule 0633 first method) is 570~710/s at 25°C (capillary inner diameter is or suitable capillary inner diameter).
acid value
take this product 5G, acid value (General 0713) shall not exceed 2.0.
saponification value
The saponification value of this product (General 0713) is 65~70.
hydroxyl value
The Hydroxyl value of this product (General 0713) is 65~78.
iodine value
The iodine value of this product (General 0713) is 25~35.
peroxide value
The peroxide value of this product (General rule 0713) not over 5.
Last Update：2022-01-01 11:27:59
61791-12-6 - Introduction
Used to emulsify and dissolve oil and other water-insoluble substances. Non-ionic solubilizer. As a solubilizer and emulsifier for water-insoluble drugs or other fat-soluble drugs, it is used in semi-solid and liquid preparations. According to the number of polymerization, it is divided into EL-10, EL-20, EL-40, EL-60, EL-80, EL-90, etc., PH(25 ℃,1%)5.0-7.0;EL-10 and EL-20 are light yellow oil, high EL-40 temperature is viscous liquid, low temperature is paste, EL-60, EL-80, and EL-90 are light yellow solids. With the increase of the number of polymerization, the water solubility gradually increases and has good emulsifying properties.
Last Update：2022-10-16 17:27:12
61791-12-6 - Differential diagnosis
Authoritative Data Verified Data
- The infrared absorption spectrum of this product should be consistent with that of polyoxyethylene (35) castor oil standard (thin film method) (General rule 0402).
- take the aqueous solution of this product (1-20), drop the bromine test solution, the bromine test solution will fade.
Last Update：2022-01-01 11:28:00
61791-12-6 - Exam
Authoritative Data Verified Data
acidity
take this product l.Og, add water 10ml to dissolve, according to the law (General 0631),pH value should be 5.0~7.0.
clarity and color of solution
take 0901G of this product, add water to dissolve 60ml, and check according to law (General rule 0902 and general rule 0902), the solution should be clear and colorless; If it is turbid, with No. 3 turbidity standard solution (general rule) comparison, not deeper; If the color, and orange 1 Standard Colorimetric liquid (General Principles 0901 first method), not deeper.
ethylene oxide and dichlorocyclo
- Take lg of this product, weigh it accurately, put it in a 10ml headspace bottle, add 1.0mL of ultrapure water accurately, seal it, shake it well, and place it at 70°C for 45 minutes. As a test solution. Measure 300ul of ethylene oxide (corresponding to 0.25g of ethylene oxide) and place 50ml of treated polyethylene glycol 400 (1.5 to 2 at 60°C). 5kPa rotary evaporation for 6 hours, remove volatile components) in a 100ml measuring flask, add before and after weighing, add the same solvent diluted to the scale, shake. As an ethylene oxide control stock solution. A stock solution of 1g of a cold ethylene oxide reference substance was accurately weighed, placed in a 50ml measuring flask containing 400 of the treated cold polyethylene glycol, and diluted to the mark with the same solvent. Take 10G for precision weighing, put it in a 50ml measuring flask containing 30ml of water, and dilute it to the scale with water. Take 10ml accurately, put it in a 50ml measuring flask, dilute it to the scale with water, and shake it well. As an ethylene oxide control solution. The appropriate amount of dioxane was accurately weighed, and the solution containing 0.1 mg per 1 ml was prepared with water as the control solution of dioxane. Take this product lg, precision weighing, top empty bottle, precision plus ethylene oxide control solution 0.5ml and dioxane control solution 0.5ml, sealed, shake. 70°C for 45 min. As a control solution. Measure 0.001% of the reference solution of ethylene oxide into a 10ml headspace bottle, and add the freshly prepared acetaldehyde solution 0.1 ml and dioxane control solution 0.1 mL, sealed, shake, 70°C for 45 minutes, as the system suitability test solution. Test according to Gas chromatography (General 0521). Quartz or glass capillary chromatographic column with polydimethylsiloxane as stationary liquid, the initial column temperature is 50°C, the temperature is maintained for 5 minutes, and the temperature is raised to 180°C at a rate of 5°C per minute, the temperature was increased to 230°C at a rate of 30°C per minute for 5 minutes (adjustable on a case by case basis). The inlet temperature was 150°C, and the detector was a flame ionization detector at a temperature of 250°C. The equilibrium temperature is 70 ° C., the equilibrium time is 45 minutes, and 1.0ml of the system suitability test solution is sampled in the headspace, the flow rate is 20cm/S, and the split ratio is 1:20. Adjust the sensitivity of the instrument so that the peak height of ethylene oxide and acetaldehyde is 15% of the full scale, the separation degree of acetaldehyde and ethylene oxide should be at least 2.0, and the peak height of dioxane should be at least 5 times higher than the baseline noise. 1.0mL of human test solution and reference solution were injected respectively in Headspace, and the injection was repeated at least 3 times. The relative standard deviation of three measurements of ethylene oxide should not exceed 15%, and the relative standard deviation of three measurements of dioxane should not exceed 10%. According to the standard plus person method, ethylene oxide shall not exceed 0.0001% and dioxane shall not exceed 0.001%.
- calibration of ethylene oxide reference stock solution 10ml of anhydrous ethanol suspension of 50% magnesium chloride was taken, and the hydrochloric acid titration solution (0.1 mol/L)20ml, mix well, place overnight, take 5g of the stock solution of ethylene oxide reference substance, precision weighing, mix the above solution, place 30 minutes, according to the potential titration method (General 0701) with potassium hydroxide ethanol titration solution (0.1 mol/L) titration, using polyethylene glycol 400 as a blank test correction, each lm l potassium hydroxide ethanol titration solution is equivalent to 4.404mg of ethylene oxide, calculation, obtained.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 0.5%.
ignition residue
take this product lg, inspection according to law (General 0841), not over 0.2%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product l. Add 10ml of magnesium nitrate hexahydrate ethanol (95%) solution (l-50) to the Crucible, slowly heat and evaporate the ethanol until burning, and add a small amount of nitric acid if there is char residue, continued burning. After cooling, add hydrochloric acid 3ml, water bath heating until the residue dissolved, according to the law (General Principles 0822 second law), should comply with the provisions (not more than 2 parts per million).
sterile (for sterile preparations without sterilization process)
take this product, according to the law inspection (General 1101), should comply with the provisions.
bacterial endotoxin (for injection)
take this product, check according to law (General rule 1143 ) , per 1 mg of polyoxyethylene (35) castor oil containing endotoxin should not exceed 0.012EU.
Last Update：2022-01-01 11:28:01
61791-12-6 - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers and solubilizers.
Last Update：2022-01-01 11:28:01
61791-12-6 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:28:01
61791-12-6 - Reference Information
| LogP | 4.297 at 25℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| shape | castor oil polyoxyethylene ether is a yellow viscous liquid, resistant to hard water, acid, alkali and inorganic salts. Used to emulsify and dissolve oil and other water-insoluble substances. Non-ionic solubilizer. Solubilizers and emulsifiers for water-insoluble drugs or other fat-soluble drugs used in semi-solid and liquid formulations |
| emulsifier | castor oil polyoxyethylene ether is also known as emulsifier EL-40, and the corresponding foreign brand name is Emulphor EL -620. It is a non-ionic surfactant. Light yellow transparent viscous liquid. Soluble in water, but also soluble in oils, fatty acids and a variety of organic solvents, the solubility in cold water than in hot water, mineral oil has good emulsifying properties. 1% aqueous solution pH = 6~8. HLB value 13. 1% aqueous solution of cloud point is greater than or equal to 85 deg C. Acid, hard water and inorganic salts, low temperature is also resistant to alkali, but strong alkali can make its hydrolysis. castor oil polyoxyethylene ether can be prepared by reacting castor oil with ethylene oxide under the catalysis of sodium hydroxide (or potassium). it is suitable for the emulsification of various vegetable oils, mineral oils, fats, waxes, etc. It can also be used as a component of an antistatic spinning finish for synthetic fibers such as polyacrylonitrile, a pesticide emulsifier, and a component of a wool thinning agent "and a wool oil. |
| Use | pesticide emulsifier, textile chemical fiber oil agent, oilfield crude oil dehydration. The textile industry is used as chemical fiber oil, the wool textile industry is used as wool oil, and the anti-static spinning oil of vinylon. Can also be used for oil wax, oleic acid and mineral oil emulsification. biochemical studies; Used to emulsify and dissolve oil and other water-insoluble substances. Non-ionic solubilizer. Solubilizers and emulsifiers for water-insoluble drugs or other fat-soluble drugs used in semi-solid and liquid formulations |
| production method | 1 mol of castor oil was added to the reaction kettle, followed by addition of 0.3% solid potassium hydroxide, equivalent to the mass of castor oil. The mixture was stirred and the temperature was raised until the KOH was dissolved. The air in the kettle was then replaced with N2. The reaction temperature was maintained at 160-180 ° C. And the pressure was 0.15-0.2 MPa. After the passage, the stirring was continued until the pressure did not drop. Cooling. The material was transferred into the bleaching kettle, the pH was adjusted to slightly acidic with acetic acid, decolorized with 0.1% hydrogen peroxide, and incubated at 70 °c for 0.5 h. The final decompression dehydration 5 h. The discharge was cooled. The reaction scheme is as follows. obtained by condensation, neutralization and decolorization of castor oil and ethylene oxide (see castor oil polyoxyethylene [90] ether for details). 04395). |
| category | toxic substances |
| toxicity grade | low toxicity |
| Acute toxicity | intravenous-mouse LD50: 6500 mg/kg |
| flammability hazard characteristics | thermal decomposition of spicy and irritating smoke |
| storage and transportation characteristics | low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 15:16:51
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