61995-20-8
1-Cbz-3-piperidinone
CAS: 61995-20-8
Molecular Formula: C13H15NO3
61995-20-8 - Names and Identifiers
| Name | 1-Cbz-3-piperidinone |
| Synonyms | N-Cbz-3-Piperidone 1-CBZ-3-PIPERIDONE 1-CBZ-3-PIPERIDINONE 1-N-Cbz-3-Piperidone 1-N-CBZ-3-PIPERIDONE 1-Cbz-3-piperidinone benzyl 3-oxopiperidine-1-carboxylate BENZYL 3-OXOPIPERIDINE-1-CARBOXYLATE 3-Oxopiperidine-1-carboxylic acid benzyl ester 3-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 1-Piperidinecarboxylic acid, 3-oxo-, phenylmethyl ester |
| CAS | 61995-20-8 |
| InChI | InChI=1/C13H15NO3/c15-12-7-4-8-14(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6H,4,7-10H2 |
61995-20-8 - Physico-chemical Properties
| Molecular Formula | C13H15NO3 |
| Molar Mass | 233.26 |
| Density | 1.212 |
| Boling Point | 384.1±42.0 °C(Predicted) |
| Flash Point | 186.1°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 4.18E-06mmHg at 25°C |
| Appearance | Liquid |
| pKa | -1.76±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.56 |
61995-20-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S60 - This material and its container must be disposed of as hazardous waste. |
| HS Code | 29333990 |
61995-20-8 - Introduction
1-Cbz-3-piperidinone is an organic compound with the chemical formula C16H17NO2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
1-Cbz-3-piperidinone is a white or light yellow solid with a distinctive odor. It is soluble in organic solvents such as methanol, ethanol and dimethylformamide, and insoluble in water. It can decompose at high temperatures.
Use:
1-Cbz-3-piperidinone is an important organic synthesis intermediate, which has a wide range of applications in drug synthesis, especially in peptide synthesis. It can be used for the synthesis of compounds with pharmaceutical activity, for example for the synthesis of peptide inhibitors, enzyme inhibitors, anticancer drugs, etc.
Preparation Method:
A commonly used preparation method is to synthesize 1-Cbz-3-piperidinone by reacting 3-piperidone with benzyl chloroformate. The reaction usually uses a base as a catalyst, and the resulting product can then be purified by crystal separation and purification to obtain pure 1-Cbz-3-piperidinone.
Safety Information:
1-Cbz-3-piperidinone is an organic compound, which should be used safely. It may cause irritation to the skin, eyes and respiratory tract, so it is necessary to wear appropriate protective equipment during operation, such as gloves, protective glasses and masks. Its specific toxicity and safety require reference to the relevant safety data sheet before use. Following the correct operating procedures and safe operation can effectively reduce the potential risks.
Nature:
1-Cbz-3-piperidinone is a white or light yellow solid with a distinctive odor. It is soluble in organic solvents such as methanol, ethanol and dimethylformamide, and insoluble in water. It can decompose at high temperatures.
Use:
1-Cbz-3-piperidinone is an important organic synthesis intermediate, which has a wide range of applications in drug synthesis, especially in peptide synthesis. It can be used for the synthesis of compounds with pharmaceutical activity, for example for the synthesis of peptide inhibitors, enzyme inhibitors, anticancer drugs, etc.
Preparation Method:
A commonly used preparation method is to synthesize 1-Cbz-3-piperidinone by reacting 3-piperidone with benzyl chloroformate. The reaction usually uses a base as a catalyst, and the resulting product can then be purified by crystal separation and purification to obtain pure 1-Cbz-3-piperidinone.
Safety Information:
1-Cbz-3-piperidinone is an organic compound, which should be used safely. It may cause irritation to the skin, eyes and respiratory tract, so it is necessary to wear appropriate protective equipment during operation, such as gloves, protective glasses and masks. Its specific toxicity and safety require reference to the relevant safety data sheet before use. Following the correct operating procedures and safe operation can effectively reduce the potential risks.
Last Update：2024-04-09 20:49:11
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CAS: 61995-20-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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