63676-22-2
2-(4-Hydroxyphenyl)-benzo[b]thiophene-6-ol
CAS: 63676-22-2
Molecular Formula: C14H10O2S
63676-22-2 - Names and Identifiers
63676-22-2 - Physico-chemical Properties
| Molecular Formula | C14H10O2S |
| Molar Mass | 242.29 |
| Density | 1.383 |
| Melting Point | 295 °C(dec.) |
| Boling Point | 477.0±30.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Pale Grey |
| pKa | 9.32±0.15(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
63676-22-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.127 ml | 20.636 ml | 41.273 ml |
| 5 mM | 0.825 ml | 4.127 ml | 8.255 ml |
| 10 mM | 0.413 ml | 2.064 ml | 4.127 ml |
| 5 mM | 0.083 ml | 0.413 ml | 0.825 ml |
Last Update：2024-01-02 23:10:35
63676-22-2 - Reference Information
| biological activity | eprogen receptor modulator 1 (compound 18) is an orally active selective eprogen receptor modulator (SERM), the pIC50 value was 0.46. Eprogen receptor modulator 1 has potential anti-tumor activity. |
| Target | Value |
| ER (Cell-free assay) | 0.46(pIC50) |
| Cell Line: | T47D:A18/PKCα and T47D:A18-TAM1 cells MCF-7:5C cells |
| Concentration: | 100 nM 100 nM |
| Incubation Time: | 10 days 9 days |
| Result: | Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation. Significantly inhibited the growth of MCF-7:5C cells. Significantly reduced tumor volume. |
| Animal Model: | 4-6 week old athymic mice (Harlan-Sprague-Dawley) |
| Dosage: | 1.5 mg/animal |
| Administration: | p.o. ; daily for 2 weeks |
Last Update：2024-04-09 19:05:13
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