63735-71-7
AEG 3482
CAS: 63735-71-7
Molecular Formula: C10H8N4O2S2
63735-71-7 - Names and Identifiers
63735-71-7 - Physico-chemical Properties
| Molecular Formula | C10H8N4O2S2 |
| Molar Mass | 280.33 |
| Density | 1.75 |
| Solubility | DMSO: ≥15mg/mL |
| Appearance | powder |
| Color | faint yellow to dark yellow |
| pKa | 5.05±0.60(Predicted) |
| Storage Condition | Store at RT |
| Use | AEG3482 is a potent anti-apoptotic compound that can induce the expression of heat shock protein 70 (HSP70) to inhibit JNK activity. AEG3482 promotes HSF1-dependent expression of HSP70 and HSP25 by directly binding HSP90. |
| Target | JNK |
63735-71-7 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
63735-71-7 - Reference
| Reference Show more | 1: Roewe J, Higer M, Riehl DR, Gericke A, Radsak MP, Bosmann M. Neuroendocrine Modulation of IL-27 in Macrophages. J Immunol. 2017 Oct 1;199(7):2503-2514. doi: 10.4049/jimmunol.1700687. Epub 2017 Aug 23. PubMed PMID: 28835457. 2: Ebenezer PJ, Weidner AM, LeVine H 3rd, Markesbery WR, Murphy MP, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Gavilán E, Keller JN. Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress. J Alzheimers Dis. 2010;22(3):839-48. doi: 10.3233/JAD-2010-101161. PubMed PMID: 20858948; PubMed Central PMCID: PMC3412400. 3: Salehi AH, Morris SJ, Ho WC, Dickson KM, Doucet G, Milutinovic S, Durkin J, Gillard JW, Barker PA. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13(2):213-23. PubMed PMID: 16492569. 4: Gallo KA. Targeting HSP90 to halt neurodegeneration. Chem Biol. 2006 Feb;13(2):115-6. PubMed PMID: 16492558. |
63735-71-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.567 ml | 17.837 ml | 35.674 ml |
| 5 mM | 0.713 ml | 3.567 ml | 7.135 ml |
| 10 mM | 0.357 ml | 1.784 ml | 3.567 ml |
| 5 mM | 0.071 ml | 0.357 ml | 0.713 ml |
Last Update：2024-01-02 23:10:35
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CAS: 63735-71-7
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CAS: 63735-71-7
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