63845-28-3

63845-28-3 - Names and Identifiers

Name	N-Cbz-4-piperidineacetic acid
Synonyms	N-CBZ-4-PIPERIDINEACETIC ACID N-Cbz-4-piperidineacetic acid 1-Cbz-4-Piperidineacetic acid Cbz-1-piperidine-4-acetic acid 1-N-CBZ-4-PIPERIDINEACETIC ACID 2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid {1-[(Benzyloxy)carbonyl]piperidin-4-yl}acetic acid 2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]-
CAS	63845-28-3
InChI	InChI=1/C15H19NO4/c17-14(18)10-12-6-8-16(9-7-12)15(19)20-11-13-4-2-1-3-5-13/h1-5,12H,6-11H2,(H,17,18)

63845-28-3 - Physico-chemical Properties

Molecular Formula	C15H19NO4
Molar Mass	277.32
Density	1.216±0.06 g/cm3(Predicted)
Boling Point	460.1±28.0 °C(Predicted)
Flash Point	232°C
Vapor Presure	2.93E-09mmHg at 25°C
pKa	4.66±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.552
MDL	MFCD02179001

63845-28-3 - Introduction

N-Cbz-4-piperidineacetic acid, also known as N-Cbz-4-piperidineacetic acid, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Usually a white crystalline solid.
-Molecular formula: C18H21NO3.
-Molecular weight: 299.36g/mol.
-Melting point: about 137-139 degrees Celsius.

Use:
N-Cbz-4-piperidineacetic acid is widely used in the field of organic synthesis and is often used in the preparation of drugs and other organic compounds. It can serve as a protecting group for pipecolic acid, which can be converted to the corresponding piperidine aldehyde or piperidinone by selective deprotection. In addition, N-Cbz-4-piperidineacetic acid can also be used as an intermediate for anti-tumor compounds.

Preparation Method:
The preparation of N-Cbz-4-piperidineacetic acid can be carried out by the following steps:
1. reacting piperidine with heterogeneous base to generate starting compound piperidine-NH-Cbz.
2. reacting piperidine-NH-Cbz with bromoacetic acid to generate N-Cbz-4-piperidine ethanol.
3. Finally, N-Cbz-4-piperidine ethanol was hydrolyzed with acid to obtain N-Cbz-4-piperidineacetic acid.

Safety Information:
N-Cbz-4-piperidineacetic acid is generally relatively safe under normal conditions of use. However, as an organic compound, it may cause irritation to the skin, eyes and respiratory system. Therefore, appropriate personal protective equipment should be worn to avoid direct contact during handling and use. In addition, contact with oxidizing agents and strong acids should be avoided during storage. If necessary, the operation should be carried out in a well-ventilated place. Before use, it is best to consult the relevant safety data sheets and operating instructions.

Last Update：2024-04-09 21:00:56