640-19-7
fluoroacetamide
CAS: 640-19-7
Molecular Formula: C2H4FNO
640-19-7 - Names and Identifiers
640-19-7 - Physico-chemical Properties
| Molecular Formula | C2H4FNO |
| Molar Mass | 77.06 |
| Density | 1.1170 (estimate) |
| Melting Point | 106-108°C(lit.) |
| Boling Point | 259.0±10.0 °C(Predicted) |
| Flash Point | 110.4°C |
| Vapor Presure | 0.0133mmHg at 25°C |
| Merck | 13,4193 |
| BRN | 1739054 |
| pKa | 14.60±0.40(Predicted) |
| Stability | Stable. |
| Refractive Index | 1.362 |
| Physical and Chemical Properties | White needle-like crystals. Melting Point 107-109 °c. Soluble in water, acetone, difficult to dissolve in chloroform, heating can sublimate, more than 170 deg C when easy to decompose. |
640-19-7 - Risk and Safety
| Risk Codes | R24 - Toxic in contact with skin R28 - Very Toxic if swallowed |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 2 |
| RTECS | AC1225000 |
| HS Code | 29241200 |
| Hazard Note | Highly Toxic/Irritant |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 i.p. in mice: 85 mg/kg (Matsumura, O'Brien) |
640-19-7 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | fluoroacetamide is used to control cotton, soybean, sorghum, wheat, Apple and other aphids, the effect of citrus and forest mites is very good, especially for cotton resistant aphids. It is also used as a rodenticide. Fluoroacetamide has a certain stimulating effect on the digestive tract mucosa. In addition to gastrointestinal symptoms, oral poisoning is mainly manifested by excessive excitement and restlessness of the central nervous system, muscle tremor, repeated episodes of paroxysmal and tonic convulsions of the whole body. Some patients have Mental Disorder, the drug is easy to damage the heart muscle. From June 5, 1982, China banned the use of pesticides and rodenticides containing fluoroacetamide, and stopped its registration. China as early as 1976 has been explicitly to stop production, in 1982, the ministry of agriculture, animal husbandry and fisheries, the Ministry of Health issued the provisions of the safe use of pesticides in the explicit provisions: Do not use fluoroacetamide as rodenticide sales and use. |
| production method | is obtained by fluorination of chloroacetamide. The fluorination reaction can be carried out in a solvent such as xylene, tetrachloroethylene or the like; A dry method (solvent-free method), I .e., a heating reaction between the dried chloroacetamide and the fluorinating agent KF, can also be used. The dry method is simple, there is no explosion-proof requirement, and the yield is higher than that of the solvent method. Dry potassium fluoride and chloroacetamide according to 1.5:1 (molar ratio) into the ball mill ball milling for half an hour, put the mixture into a preheated horizontal fluorination kettle, heat reaction under reduced pressure, fluoroacetamide with a content of 95% was obtained in a yield of 72-75%. |
| category | pesticide |
| toxicity grade | highly toxic |
| Acute toxicity | oral-rat LD50: 5.75 mg/kg; Oral-mouse LD50: 25 mg/kg |
| flammability hazard characteristics | flammable in case of open flame and high heat; decomposition of toxic fluoride and nitrogen oxide gases by heat or acid |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| fire extinguishing agent | water, sand, carbon dioxide |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
