64218-02-6

64218-02-6 - Names and Identifiers

Name	2,6-OCTADIENE-1,8-DIOL, 2-[(3E)-4,8-DIMETHYL-3,7-NONADIENYL]-6-METHYL-, (2Z,6E)-
Synonyms	Kelnac CS-684 Kelnal Plaunotoi Plaugenol (2E,6Z,10E)-7-Hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetren-1-ol (2Z,6E)-2-[(3E)-4,8-Dimethyl-3,7-nonadienyl]-6-methyl-2,6-octadiene-1,8-diol 2,6-OCTADIENE-1,8-DIOL, 2-[(3E)-4,8-DIMETHYL-3,7-NONADIENYL]-6-METHYL-, (2Z,6E)-
CAS	64218-02-6

64218-02-6 - Physico-chemical Properties

Molecular Formula	C20H34O2
Molar Mass	306.48
Density	0.936±0.06 g/cm3(Predicted)
Boling Point	440.4±45.0 °C(Predicted)
pKa	14.40±0.10(Predicted)
Storage Condition	2-8°C
Physical and Chemical Properties	Pale yellow oil, fragrant and bitter. Soluble in benzene, acetone, alcohol or ether, insoluble in water. Acute toxicity LD50 male and female mice, male and female rats (μl/kg,1 μl-equivalent to 0.95mg of refined oil):8800,8180,10900,11200 oral administration; 35500,44000,29500,35000 subcutaneous injection.

64218-02-6 - Risk and Safety

Toxicity

LD50 in male, female mice, rats (ml/kg): 8800, 8100, 10900, 11200 orally (Kobayashi)

64218-02-6 - References

Usage

Defense factor-enhanced anti-ulcer drug. For gastric ulcer.

production method

from the stems and leaves of Croton sulblyratus Kurz, a plant of the genus Croton of the Euphorbiaceae in Thailand (the commodity is plaoi) extraction of active ingredients. 81.5kg of commercial Hau-noi were pulverized and extracted three times with acetone under reflux. After the extract was concentrated, the residue was dissolved in 10L of a 80% aqueous methanol solution and washed with n-hexane. The methanol layer was concentrated and poured into 40L of benzene with vigorous stirring. The benzene solution was concentrated and the residue was extracted with ether. The ether solution was chromatographed on a 3kg column of silica gel, eluting with benzene and ethyl acetate, to give 53g of pranolol. The insoluble matter extracted by ether, with 5kg Silica Gel chromatography, chloroform and methanol elution, can be obtained 12 gfuranodaterpenea [melting point 180~181 ℃,[α]D20-142 °(C = 1.0, acetone)] and 28gfuranoditerpeneb [melting point 170-172 °c,[α]D20-144 °(C = 1.0, acetone)], both of which have the same activity as pranolol. An attempt has also been made on the total synthesis of pranolol.

Last Update：2024-04-10 22:29:15